Active cytomegalovirus particles in the eyes of an AIDS patient being treated with 9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (Ganciclovir).

Journal Article (Journal Article)

The eyes of an AIDS patient with cytomegalovirus (CMV) retinitis and pneumonitis who died while receiving maintenance therapy with the antiviral agent 9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (Ganciclovir) were obtained for pathological examination. While under treatment the patient had significant improvement but not complete regression of retinitis. Electron microscopic and immunofluorescent techniques revealed cytomegalovirus particles in the retina, sclera, iris, and ciliary body. These findings are consistent with a virostatic type of inhibition of CMV by this agent. They also suggest that CMV involvement in the eye and other organs may be more widespread than is clinically apparent in AIDS patients.

Full Text

Duke Authors

Cited Authors

  • Teich, SA; Castle, J; Friedman, AH; Siroty, W; Orellana, J; Schmitterer, M

Published Date

  • April 1, 1988

Published In

Volume / Issue

  • 72 / 4

Start / End Page

  • 293 - 298

PubMed ID

  • 2837272

Pubmed Central ID

  • PMC1041436

International Standard Serial Number (ISSN)

  • 0007-1161

Digital Object Identifier (DOI)

  • 10.1136/bjo.72.4.293


  • eng

Conference Location

  • England