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Combined short- and long-term therapy for the treatment of cytomegalovirus retinitis using ganciclovir (BW B759U).

Publication ,  Journal Article
Orellana, J; Teich, SA; Friedman, AH; Lerebours, F; Winterkorn, J; Mildvan, D
Published in: Ophthalmology
July 1987

A total of 66 eyes in 41 patients were treated for cytomegalovirus (CMV) retinitis with a new acyclic nucleoside, ganciclovir (BW B759U). At the completion of the short-term therapy period of 21 days, 87.7% of eyes had stabilized or improved. Seventy-two percent of eyes stabilized or improved during long-term home maintenance therapy. Leukopenia and increased liver function abnormalities were the most common adverse drug reactions seen in this series. Ganciclovir dramatically improved the quality of life in these patients, but clinical evidence suggests that it is a virostatic medication requiring indefinite long-term maintenance therapy.

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Published In

Ophthalmology

DOI

ISSN

0161-6420

Publication Date

July 1987

Volume

94

Issue

7

Start / End Page

831 / 838

Location

United States

Related Subject Headings

  • Time Factors
  • Retinitis
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Liver
  • Leukocyte Count
  • Humans
  • Ganciclovir
  • Female
 

Citation

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ICMJE
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Orellana, J., Teich, S. A., Friedman, A. H., Lerebours, F., Winterkorn, J., & Mildvan, D. (1987). Combined short- and long-term therapy for the treatment of cytomegalovirus retinitis using ganciclovir (BW B759U). Ophthalmology, 94(7), 831–838. https://doi.org/10.1016/s0161-6420(87)33536-5
Orellana, J., S. A. Teich, A. H. Friedman, F. Lerebours, J. Winterkorn, and D. Mildvan. “Combined short- and long-term therapy for the treatment of cytomegalovirus retinitis using ganciclovir (BW B759U).Ophthalmology 94, no. 7 (July 1987): 831–38. https://doi.org/10.1016/s0161-6420(87)33536-5.
Orellana J, Teich SA, Friedman AH, Lerebours F, Winterkorn J, Mildvan D. Combined short- and long-term therapy for the treatment of cytomegalovirus retinitis using ganciclovir (BW B759U). Ophthalmology. 1987 Jul;94(7):831–8.
Orellana, J., et al. “Combined short- and long-term therapy for the treatment of cytomegalovirus retinitis using ganciclovir (BW B759U).Ophthalmology, vol. 94, no. 7, July 1987, pp. 831–38. Pubmed, doi:10.1016/s0161-6420(87)33536-5.
Orellana J, Teich SA, Friedman AH, Lerebours F, Winterkorn J, Mildvan D. Combined short- and long-term therapy for the treatment of cytomegalovirus retinitis using ganciclovir (BW B759U). Ophthalmology. 1987 Jul;94(7):831–838.
Journal cover image

Published In

Ophthalmology

DOI

ISSN

0161-6420

Publication Date

July 1987

Volume

94

Issue

7

Start / End Page

831 / 838

Location

United States

Related Subject Headings

  • Time Factors
  • Retinitis
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Liver
  • Leukocyte Count
  • Humans
  • Ganciclovir
  • Female