Combined short- and long-term therapy for the treatment of cytomegalovirus retinitis using ganciclovir (BW B759U).

Journal Article (Journal Article)

A total of 66 eyes in 41 patients were treated for cytomegalovirus (CMV) retinitis with a new acyclic nucleoside, ganciclovir (BW B759U). At the completion of the short-term therapy period of 21 days, 87.7% of eyes had stabilized or improved. Seventy-two percent of eyes stabilized or improved during long-term home maintenance therapy. Leukopenia and increased liver function abnormalities were the most common adverse drug reactions seen in this series. Ganciclovir dramatically improved the quality of life in these patients, but clinical evidence suggests that it is a virostatic medication requiring indefinite long-term maintenance therapy.

Full Text

Duke Authors

Cited Authors

  • Orellana, J; Teich, SA; Friedman, AH; Lerebours, F; Winterkorn, J; Mildvan, D

Published Date

  • July 1, 1987

Published In

Volume / Issue

  • 94 / 7

Start / End Page

  • 831 - 838

PubMed ID

  • 2821466

International Standard Serial Number (ISSN)

  • 0161-6420

Digital Object Identifier (DOI)

  • 10.1016/s0161-6420(87)33536-5


  • eng

Conference Location

  • United States