New findings in the chromosome 13 long-arm deletion syndrome and retinoblastoma.
Journal Article (Journal Article)
New clinical and pathologic findings in patients with deletion of the long arm of chromosome 13 (13q-) include optic nerve hypoplasia and retinal dysplasia. Fibroblasts derived from patients with a 13q- syndrome with and without retinoblastoma, as well as from familial and sporadic retinoblastoma, are a useful model for the study of genetic susceptibility to the development of spontaneous and radiation-induced cancers. Fibroblasts from patients with hereditary retinoblastoma appear more radiosensitive than fibroblasts from patients with sporadic retinoblastoma or normal control patients.
Full Text
Duke Authors
Cited Authors
- Weichselbaum, RR; Zakov, ZN; Albert, DM; Friedman, AH; Nove, J; Little, JB
Published Date
- June 1, 1979
Published In
Volume / Issue
- 86 / 6
Start / End Page
- 1191 - 1201
PubMed ID
- 118416
Pubmed Central ID
- 118416
International Standard Serial Number (ISSN)
- 0161-6420
Digital Object Identifier (DOI)
- 10.1016/s0161-6420(79)35429-x
Language
- eng
Conference Location
- United States