New findings in the chromosome 13 long-arm deletion syndrome and retinoblastoma.

Journal Article (Journal Article)

New clinical and pathologic findings in patients with deletion of the long arm of chromosome 13 (13q-) include optic nerve hypoplasia and retinal dysplasia. Fibroblasts derived from patients with a 13q- syndrome with and without retinoblastoma, as well as from familial and sporadic retinoblastoma, are a useful model for the study of genetic susceptibility to the development of spontaneous and radiation-induced cancers. Fibroblasts from patients with hereditary retinoblastoma appear more radiosensitive than fibroblasts from patients with sporadic retinoblastoma or normal control patients.

Full Text

Duke Authors

Cited Authors

  • Weichselbaum, RR; Zakov, ZN; Albert, DM; Friedman, AH; Nove, J; Little, JB

Published Date

  • June 1, 1979

Published In

Volume / Issue

  • 86 / 6

Start / End Page

  • 1191 - 1201

PubMed ID

  • 118416

International Standard Serial Number (ISSN)

  • 0161-6420

Digital Object Identifier (DOI)

  • 10.1016/s0161-6420(79)35429-x


  • eng

Conference Location

  • United States