TREMORINE: ITS EFFECT ON AMINES OF THE CENTRAL NERVOUS SYSTEM.

Journal Article

The administration of tremogenidine doses of Tremorine, 1,4-dipyrrolidino-2 butyne, is followed by a significant decrease in the concentration of norepinephrine in the brain stem of three common laboratory species. The change in the concentration proceeds at a rate which coincides with the occurrence of the tremor in each of these species. In the rat, the change in norepinephrine is followed by a progressive increase in the concentration of 5-hydroxytryptamine in the brain stem. Bilateral adrenalectomy in the rat enhances the Tremorine-induced changes in the concentration of norepinephrine and antagonizes the increase in the concentration of S-hydroxytryptamine.

Full Text

Duke Authors

Cited Authors

  • FRIEDMAN, AH; AYLESWORTH, RJ; FRIEDMAN, G

Published Date

  • September 20, 1963

Published In

Volume / Issue

  • 141 / 3586

Start / End Page

  • 1188 - 1190

PubMed ID

  • 14043364

International Standard Serial Number (ISSN)

  • 0036-8075

Language

  • eng

Conference Location

  • United States