TREMORINE: ITS EFFECT ON AMINES OF THE CENTRAL NERVOUS SYSTEM.
Journal Article (Journal Article)
The administration of tremogenidine doses of Tremorine, 1,4-dipyrrolidino-2 butyne, is followed by a significant decrease in the concentration of norepinephrine in the brain stem of three common laboratory species. The change in the concentration proceeds at a rate which coincides with the occurrence of the tremor in each of these species. In the rat, the change in norepinephrine is followed by a progressive increase in the concentration of 5-hydroxytryptamine in the brain stem. Bilateral adrenalectomy in the rat enhances the Tremorine-induced changes in the concentration of norepinephrine and antagonizes the increase in the concentration of S-hydroxytryptamine.
Full Text
Duke Authors
Cited Authors
- FRIEDMAN, AH; AYLESWORTH, RJ; FRIEDMAN, G
Published Date
- September 20, 1963
Published In
Volume / Issue
- 141 / 3586
Start / End Page
- 1188 - 1190
PubMed ID
- 14043364
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.141.3586.1188
Language
- eng
Conference Location
- United States