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Systemic antiviral drugs used in ophthalmology.

Publication ,  Journal Article
Teich, SA; Cheung, TW; Friedman, AH
Published in: Surv Ophthalmol
1992

Over the past two decades, the recognition of viral enzymes and proteins that can serve as molecular targets of drugs has revolutionized the treatment of viral infections. Beginning with acyclovir, a number of systemically administered agents which are both relatively safe and effective for the treatment of herpetic infections and human immunodeficiency virus (HIV) infections have become widely available. Because of increased numbers of herpes virus infections, as well as the rising epidemic of HIV infections, the ophthalmologist is, more likely than ever before to be involved in the treatment of severe and frequent ocular infections caused by herpes viruses. In addition, the acute retinal necrosis (ARN) syndrome has been demonstrated to be caused by herpes viruses and a once rare retinal infection caused by cytomegalovirus is common in patients with the acquired immunodeficiency syndrome (AIDS). In this article, four systemic antiviral drugs (Vidarabine, Acyclovir, Ganciclovir, and Foscarnet) that have demonstrated usefulness in the treatment of ophthalmic disease are reviewed in detail with regard to their mechanisms, applications, effectiveness, and side effects.

Duke Scholars

Published In

Surv Ophthalmol

DOI

ISSN

0039-6257

Publication Date

1992

Volume

37

Issue

1

Start / End Page

19 / 53

Location

United States

Related Subject Headings

  • Zidovudine
  • Vidarabine
  • Recombinant Proteins
  • Phosphonoacetic Acid
  • Ophthalmology & Optometry
  • Keratitis, Herpetic
  • Interferon-alpha
  • Interferon alpha-2
  • Humans
  • Ganciclovir
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Teich, S. A., Cheung, T. W., & Friedman, A. H. (1992). Systemic antiviral drugs used in ophthalmology. Surv Ophthalmol, 37(1), 19–53. https://doi.org/10.1016/0039-6257(92)90003-c
Teich, S. A., T. W. Cheung, and A. H. Friedman. “Systemic antiviral drugs used in ophthalmology.Surv Ophthalmol 37, no. 1 (1992): 19–53. https://doi.org/10.1016/0039-6257(92)90003-c.
Teich SA, Cheung TW, Friedman AH. Systemic antiviral drugs used in ophthalmology. Surv Ophthalmol. 1992;37(1):19–53.
Teich, S. A., et al. “Systemic antiviral drugs used in ophthalmology.Surv Ophthalmol, vol. 37, no. 1, 1992, pp. 19–53. Pubmed, doi:10.1016/0039-6257(92)90003-c.
Teich SA, Cheung TW, Friedman AH. Systemic antiviral drugs used in ophthalmology. Surv Ophthalmol. 1992;37(1):19–53.
Journal cover image

Published In

Surv Ophthalmol

DOI

ISSN

0039-6257

Publication Date

1992

Volume

37

Issue

1

Start / End Page

19 / 53

Location

United States

Related Subject Headings

  • Zidovudine
  • Vidarabine
  • Recombinant Proteins
  • Phosphonoacetic Acid
  • Ophthalmology & Optometry
  • Keratitis, Herpetic
  • Interferon-alpha
  • Interferon alpha-2
  • Humans
  • Ganciclovir