Sclero-cornea and defective mesodermal migration.

Journal Article (Journal Article)

A 5-month-old boy with bilateral sclero-cornea, multiple systemic abnormalities, and normal karyotype had his left eye removed after corneal perforation. Histopathological examination of the enucleated eye revealed an irregular corneal epithelium, absent Bowman's membrane, thickened and vascularized stromal lamellae, absent Descemet's membrane and endothelium, no angle structures, hypoplasia of the iris and ciliary body, and total kerato-iridic adhesions. A profound defect in embryogenesis due to defective mesodermal migration during the earliest phase of mesoderm differentiation is postulated as the causative factor in this case.

Full Text

Duke Authors

Cited Authors

  • Friedman, AH; Weingeist, S; Brackup, A; Marinoff, G

Published Date

  • November 1, 1975

Published In

Volume / Issue

  • 59 / 11

Start / End Page

  • 683 - 687

PubMed ID

  • 1203220

Pubmed Central ID

  • PMC1017433

International Standard Serial Number (ISSN)

  • 0007-1161

Digital Object Identifier (DOI)

  • 10.1136/bjo.59.11.683


  • eng

Conference Location

  • England