Association and chance occurrence of aniridia and retinoblastoma.
Journal Article (Journal Article)
PURPOSE/METHODS: A 9-month-old infant had inherited aniridia and unilateral retinoblastoma. Family history disclosed three generations of aniridia; yet there were no instances of retinoblastoma. The coincidental occurrence of retinoblastoma and aniridia is rare. RESULTS/CONCLUSIONS: With DNA probes from within the retinoblastoma gene, we were able to determine that a retinoblastoma-predisposing mutation was not inherited with aniridia in this family. The occurrence of these two diseases in the same individual therefore represents a chance event.
Full Text
Duke Authors
Cited Authors
- To, KW; Mukai, S; Friedman, AH
Published Date
- December 15, 1994
Published In
Volume / Issue
- 118 / 6
Start / End Page
- 820 - 822
PubMed ID
- 7977618
International Standard Serial Number (ISSN)
- 0002-9394
Digital Object Identifier (DOI)
- 10.1016/s0002-9394(14)72571-1
Language
- eng
Conference Location
- United States