TXNIP links redox circuitry to glucose control.


Journal Article

Thioredoxin-interacting protein (TXNIP) binds and inhibits the reducing activity of thioredoxin. A new study (Parikh et al., 2007) implicates this redox rheostat as a negative regulator of peripheral glucose metabolism in humans. Investigators combined human physiology, genomic screening, and cell-based genetic studies to highlight TNXIP as a potential culprit in the pathogenesis of type 2 diabetes.

Full Text

Duke Authors

Cited Authors

  • Muoio, DM

Published Date

  • June 2007

Published In

Volume / Issue

  • 5 / 6

Start / End Page

  • 412 - 414

PubMed ID

  • 17550776

Pubmed Central ID

  • 17550776

Electronic International Standard Serial Number (EISSN)

  • 1932-7420

Digital Object Identifier (DOI)

  • 10.1016/j.cmet.2007.05.011


  • eng

Conference Location

  • United States