Depressed mothers use less of the exaggerated prosody that is typical of infant-directed (ID) speech than do nondepressed mothers. We investigated the consequences of this reduced perceptual salience in ID speech for infant learning. Infants of nondepressed mothers readily learned that their mothers' speech signaled a face, whereas infants of depressed mothers failed to learn that their mothers' speech signaled the face. Infants of depressed mothers did, however, show strong learning in response to speech produced by an unfamiliar nondepressed mother. These outcomes indicate that the reduced perceptual salience of depressed mothers' ID speech could lead to deficient learning in otherwise competent learners.