Evaluation of penicillin and hyperbaric oxygen in the treatment of streptococcal myositis.
Journal Article (Journal Article)
The purpose of this study was to evaluate effects of hyperbaric oxygen (HBO) and penicillin (PCN) therapy in a murine model of streptococcal myositis. The thighs of Swiss Webster mice were inoculated with Streptococcus pyogenes. Four groups were evaluated: (1) control (N = 10), (2) HBO treatment (N = 10), (3) PCN treatment (N = 8), and (4) PCN and HBO treatment (N = 6). Mortality (day of death) and the number of colony-forming units (cfu) were measured. PCN significantly lowered cfu from control (p < 0.05). Cfu in group 4 was significantly lower than PCN alone (p = 0.006). Survival was significantly longer in the PCN group compared with the control (p < 0.01). Survival in the combined treatment group was significantly longer than PCN alone (p < 0.01). These results suggest that (1) HBO treatment alone does not decrease mortality or bacterial proliferation in vivo significantly, (2) PCN therapy alone improves outcome significantly, and (3) the combined treatment of PCN and HBO exerts at least additive effects in both decreasing bacterial counts in vivo and increasing survival in this model.
Full Text
Duke Authors
Cited Authors
- Zamboni, WA; Mazolewski, PJ; Erdmann, D; Bergman, BA; Hussman, J; Cooper, MD; Smoot, EC; Russell, RC
Published Date
- August 1997
Published In
Volume / Issue
- 39 / 2
Start / End Page
- 131 - 136
PubMed ID
- 9262765
Pubmed Central ID
- 9262765
International Standard Serial Number (ISSN)
- 0148-7043
Digital Object Identifier (DOI)
- 10.1097/00000637-199708000-00004
Language
- eng
Conference Location
- United States