The use of cultured Schwann cells in nerve repair in a rabbit hind-limb model.

Journal Article (Journal Article)

A 3-cm peripheral nerve gap in a rabbit hind-limb model was repaired by using a polyglycolic acid (PGA) conduit filled with a gelatin/Schwann-cell suspension. Postoperative nerve function after 16 weeks, as measured by isometric twitch and tetanic muscle strengths, and nerve conduction velocities, failed to demonstrate a statistically significant difference, compared to a control group in which the nerve gap was reconstructed by using a PGA conduit filled with gelatin only. The 3-cm gap in the described model may not have been long enough to show a significant difference between the two groups. Alternatively, the transferred cultured Schwann cells may have been functionally inactive.

Full Text

Duke Authors

Cited Authors

  • Brown, RE; Erdmann, D; Lyons, SF; Suchy, H

Published Date

  • April 1996

Published In

Volume / Issue

  • 12 / 3

Start / End Page

  • 149 - 152

PubMed ID

  • 8726333

International Standard Serial Number (ISSN)

  • 0743-684X

Digital Object Identifier (DOI)

  • 10.1055/s-2007-1006468


  • eng

Conference Location

  • United States