[New developments in skin replacement materials].

Journal Article (English Abstract;Journal Article)

Current treatment strategies in intensive care medicine permit survival of patients with burns of more than 80% of the total body surface area (TBSA). Major burns result in extensive skin defects. Thus, burn victims often suffer from scar contractures, altered thermoregulation, and unsatisfactory cosmetic results. In addition to the well-established cultivated epithelial autografts, a number of new composite grafts have been developed in the field of tissue engineering. The combination of synthetic and allogenic matrix structures together with an allogenic or autologous epithelium allows the possibility of mimicking skin structure. The aim is to achieve improved wound healing by regeneration of dermal tissue instead of scarring. This article provides an overview of the currently available products which have already been introduced into clinical routine as well as describing advantages and disadvantages of the individual products and their indications.

Full Text

Duke Authors

Cited Authors

  • Przybilski, M; Deb, R; Erdmann, D; Germann, G

Published Date

  • June 2004

Published In

Volume / Issue

  • 75 / 6

Start / End Page

  • 579 - 587

PubMed ID

  • 15221092

International Standard Serial Number (ISSN)

  • 0009-4722

Digital Object Identifier (DOI)

  • 10.1007/s00104-004-0860-6


  • ger

Conference Location

  • Germany