Skin allograft rejection and hyperbaric oxygen treatment in immune-histoincompatible mice.

Journal Article (Journal Article)

The effect of hyperbaric oxygen (HBO) as an immunosuppressive agent was evaluated by using a highly immunogenic skin allograft mouse model. Immune-histoincompatible female C57BL/6 and BALB/c mice (N = 30) were randomly assigned to three groups receiving no treatment (control group), low dose HBO treatment (two treatments once a week), and intermediate HBO treatment (two treatments 3 times/wk) 1 wk before and 2 wk after transplantation of a 1.5 x 2 cm full thickness skin allograft from the back. Rejection was observed a Day 7 and was completed 14 days after surgery in controls. Low dose and intermediate HBO treatment delayed skin allograft rejection, which was histologically confirmed.

Full Text

Duke Authors

Cited Authors

  • Erdmann, D; Roth, AC; Hussmann, J; Lyons, SF; Mody, NJ; Kucan, JO; Russell, RC

Published Date

  • December 1995

Published In

Volume / Issue

  • 22 / 4

Start / End Page

  • 395 - 399

PubMed ID

  • 8574127

International Standard Serial Number (ISSN)

  • 1066-2936


  • eng

Conference Location

  • United States