Skin allograft rejection and hyperbaric oxygen treatment in immune-histoincompatible mice.
Journal Article (Journal Article)
The effect of hyperbaric oxygen (HBO) as an immunosuppressive agent was evaluated by using a highly immunogenic skin allograft mouse model. Immune-histoincompatible female C57BL/6 and BALB/c mice (N = 30) were randomly assigned to three groups receiving no treatment (control group), low dose HBO treatment (two treatments once a week), and intermediate HBO treatment (two treatments 3 times/wk) 1 wk before and 2 wk after transplantation of a 1.5 x 2 cm full thickness skin allograft from the back. Rejection was observed a Day 7 and was completed 14 days after surgery in controls. Low dose and intermediate HBO treatment delayed skin allograft rejection, which was histologically confirmed.
Full Text
Duke Authors
Cited Authors
- Erdmann, D; Roth, AC; Hussmann, J; Lyons, SF; Mody, NJ; Kucan, JO; Russell, RC
Published Date
- December 1995
Published In
Volume / Issue
- 22 / 4
Start / End Page
- 395 - 399
PubMed ID
- 8574127
International Standard Serial Number (ISSN)
- 1066-2936
Language
- eng
Conference Location
- United States