Skin allograft rejection and hyperbaric oxygen treatment in immune-histoincompatible mice.
Publication
, Journal Article
Erdmann, D; Roth, AC; Hussmann, J; Lyons, SF; Mody, NJ; Kucan, JO; Russell, RC
Published in: Undersea Hyperb Med
December 1995
The effect of hyperbaric oxygen (HBO) as an immunosuppressive agent was evaluated by using a highly immunogenic skin allograft mouse model. Immune-histoincompatible female C57BL/6 and BALB/c mice (N = 30) were randomly assigned to three groups receiving no treatment (control group), low dose HBO treatment (two treatments once a week), and intermediate HBO treatment (two treatments 3 times/wk) 1 wk before and 2 wk after transplantation of a 1.5 x 2 cm full thickness skin allograft from the back. Rejection was observed a Day 7 and was completed 14 days after surgery in controls. Low dose and intermediate HBO treatment delayed skin allograft rejection, which was histologically confirmed.
Duke Scholars
Published In
Undersea Hyperb Med
ISSN
1066-2936
Publication Date
December 1995
Volume
22
Issue
4
Start / End Page
395 / 399
Location
United States
Related Subject Headings
- Surgical Flaps
- Random Allocation
- Physiology
- Mice, Inbred C57BL
- Mice, Inbred BALB C
- Mice
- Immunocompetence
- Hyperbaric Oxygenation
- Graft Rejection
- Female
Citation
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MLA
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Erdmann, D., Roth, A. C., Hussmann, J., Lyons, S. F., Mody, N. J., Kucan, J. O., & Russell, R. C. (1995). Skin allograft rejection and hyperbaric oxygen treatment in immune-histoincompatible mice. Undersea Hyperb Med, 22(4), 395–399.
Erdmann, D., A. C. Roth, J. Hussmann, S. F. Lyons, N. J. Mody, J. O. Kucan, and R. C. Russell. “Skin allograft rejection and hyperbaric oxygen treatment in immune-histoincompatible mice.” Undersea Hyperb Med 22, no. 4 (December 1995): 395–99.
Erdmann D, Roth AC, Hussmann J, Lyons SF, Mody NJ, Kucan JO, et al. Skin allograft rejection and hyperbaric oxygen treatment in immune-histoincompatible mice. Undersea Hyperb Med. 1995 Dec;22(4):395–9.
Erdmann, D., et al. “Skin allograft rejection and hyperbaric oxygen treatment in immune-histoincompatible mice.” Undersea Hyperb Med, vol. 22, no. 4, Dec. 1995, pp. 395–99.
Erdmann D, Roth AC, Hussmann J, Lyons SF, Mody NJ, Kucan JO, Russell RC. Skin allograft rejection and hyperbaric oxygen treatment in immune-histoincompatible mice. Undersea Hyperb Med. 1995 Dec;22(4):395–399.
Published In
Undersea Hyperb Med
ISSN
1066-2936
Publication Date
December 1995
Volume
22
Issue
4
Start / End Page
395 / 399
Location
United States
Related Subject Headings
- Surgical Flaps
- Random Allocation
- Physiology
- Mice, Inbred C57BL
- Mice, Inbred BALB C
- Mice
- Immunocompetence
- Hyperbaric Oxygenation
- Graft Rejection
- Female