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Four-dimensional MR microscopy of the mouse heart using radial acquisition and liposomal gadolinium contrast agent.

Publication ,  Journal Article
Bucholz, E; Ghaghada, K; Qi, Y; Mukundan, S; Johnson, GA
Published in: Magn Reson Med
July 2008

Magnetic resonance microscopy (MRM) has become an important tool for small animal cardiac imaging. In relation to competing technologies (microCT and ultrasound), MR is limited by spatial resolution, temporal resolution, and acquisition time. All three of these limitations have been addressed by developing a four-dimensional (4D) (3D plus time) radial acquisition (RA) sequence. The signal-to-noise ratio (SNR) has been optimized by minimizing the echo time (TE) (300 us). The temporal resolution and throughput have been improved by center-out trajectories resulting in repetition time (TR) <2.5 ms. The contrast has been enhanced through the use of a liposomal blood pool agent that reduces the T(1) of the blood to <400 ms. We have developed protocols for three specific applications: 1) high-throughput with spatial resolution of 87 x 87 x 352 um(3) (voxel volume = 2.7 nL) and acquisition time of 16 min; 2) high-temporal resolution with spatial resolution of 87 x 87 x 352 um(3) (voxel volume = 2.7 nL) and temporal resolution at 4.8 ms and acquisition time of 32 minutes; and 3) high-resolution isotropic imaging at 87 x 87 x 87 um(3) (voxel volume = 0.68 nL) and acquisition time of 31 min. The 4D image arrays allow direct measure of cardiac functional parameters dependent on chamber volumes, e.g., ejection fraction (EF), end diastolic volume (EDV), and end systolic volume (ESV).

Duke Scholars

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

July 2008

Volume

60

Issue

1

Start / End Page

111 / 118

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Microscopy
  • Mice
  • Magnetic Resonance Imaging
  • Liposomes
  • Heart
  • Gadolinium
  • Contrast Media
  • Animals
  • 4003 Biomedical engineering
 

Citation

APA
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ICMJE
MLA
NLM
Bucholz, E., Ghaghada, K., Qi, Y., Mukundan, S., & Johnson, G. A. (2008). Four-dimensional MR microscopy of the mouse heart using radial acquisition and liposomal gadolinium contrast agent. Magn Reson Med, 60(1), 111–118. https://doi.org/10.1002/mrm.21618
Bucholz, Elizabeth, Ketan Ghaghada, Yi Qi, Srinivasan Mukundan, and G Allan Johnson. “Four-dimensional MR microscopy of the mouse heart using radial acquisition and liposomal gadolinium contrast agent.Magn Reson Med 60, no. 1 (July 2008): 111–18. https://doi.org/10.1002/mrm.21618.
Bucholz E, Ghaghada K, Qi Y, Mukundan S, Johnson GA. Four-dimensional MR microscopy of the mouse heart using radial acquisition and liposomal gadolinium contrast agent. Magn Reson Med. 2008 Jul;60(1):111–8.
Bucholz, Elizabeth, et al. “Four-dimensional MR microscopy of the mouse heart using radial acquisition and liposomal gadolinium contrast agent.Magn Reson Med, vol. 60, no. 1, July 2008, pp. 111–18. Pubmed, doi:10.1002/mrm.21618.
Bucholz E, Ghaghada K, Qi Y, Mukundan S, Johnson GA. Four-dimensional MR microscopy of the mouse heart using radial acquisition and liposomal gadolinium contrast agent. Magn Reson Med. 2008 Jul;60(1):111–118.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

July 2008

Volume

60

Issue

1

Start / End Page

111 / 118

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Microscopy
  • Mice
  • Magnetic Resonance Imaging
  • Liposomes
  • Heart
  • Gadolinium
  • Contrast Media
  • Animals
  • 4003 Biomedical engineering