Skip to main content
Journal cover image

Pulmonary perfusion imaging in the rodent lung using dynamic contrast-enhanced MRI.

Publication ,  Journal Article
Mistry, NN; Pollaro, J; Song, J; De Lin, M; Johnson, GA
Published in: Magn Reson Med
February 2008

With the development of various models of pulmonary disease, there is tremendous interest in quantitative regional assessment of pulmonary function. While ventilation imaging has been addressed to a certain extent, perfusion imaging for small animals has not kept pace. In humans and large animals perfusion can be assessed using dynamic contrast-enhanced (DCE) MRI with a single bolus injection of a gadolinium (Gd)-based contrast agent. But the method developed for the clinic cannot be translated directly to image the rodent due to the combined requirements of higher spatial and temporal resolution. This work describes a novel image acquisition technique staggered over multiple, repeatable bolus injections of contrast agent using an automated microinjector, synchronized with image acquisition to achieve dynamic first-pass contrast enhancement in the rat lung. This allows dynamic first-pass imaging that can be used to quantify pulmonary perfusion. Further improvements are made in the spatial and temporal resolution by combining the multiple injection acquisition method with Interleaved Radial Imaging and "Sliding window-keyhole" reconstruction (IRIS). The results demonstrate a simultaneous increase in spatial resolution (<200 mum) and temporal resolution (<200 ms) over previous methods, with a limited loss in signal-to-noise-ratio.

Duke Scholars

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

February 2008

Volume

59

Issue

2

Start / End Page

289 / 297

Location

United States

Related Subject Headings

  • Rats, Inbred F344
  • Rats
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Lung
  • Image Processing, Computer-Assisted
  • Gadolinium DTPA
  • Female
  • Contrast Media
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mistry, N. N., Pollaro, J., Song, J., De Lin, M., & Johnson, G. A. (2008). Pulmonary perfusion imaging in the rodent lung using dynamic contrast-enhanced MRI. Magn Reson Med, 59(2), 289–297. https://doi.org/10.1002/mrm.21353
Mistry, Nilesh N., James Pollaro, Jiayu Song, Ming De Lin, and G Allan Johnson. “Pulmonary perfusion imaging in the rodent lung using dynamic contrast-enhanced MRI.Magn Reson Med 59, no. 2 (February 2008): 289–97. https://doi.org/10.1002/mrm.21353.
Mistry NN, Pollaro J, Song J, De Lin M, Johnson GA. Pulmonary perfusion imaging in the rodent lung using dynamic contrast-enhanced MRI. Magn Reson Med. 2008 Feb;59(2):289–97.
Mistry, Nilesh N., et al. “Pulmonary perfusion imaging in the rodent lung using dynamic contrast-enhanced MRI.Magn Reson Med, vol. 59, no. 2, Feb. 2008, pp. 289–97. Pubmed, doi:10.1002/mrm.21353.
Mistry NN, Pollaro J, Song J, De Lin M, Johnson GA. Pulmonary perfusion imaging in the rodent lung using dynamic contrast-enhanced MRI. Magn Reson Med. 2008 Feb;59(2):289–297.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

February 2008

Volume

59

Issue

2

Start / End Page

289 / 297

Location

United States

Related Subject Headings

  • Rats, Inbred F344
  • Rats
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Lung
  • Image Processing, Computer-Assisted
  • Gadolinium DTPA
  • Female
  • Contrast Media