ApoE genotype-specific inhibition of apoptosis.
Journal Article (Journal Article)
Endothelial cell apoptosis can be initiated by withdrawing growth factors or serum, and is inhibited by HDL. Our results show that the total lipoprotein population from apolipoprotein E 4/4 (APOE4/4) sera is less anti-apoptotic than total lipoproteins from other APOE genotypes, as measured by caspase 3/7 activity. Moreover, APOE4/4 VLDL antagonizes the antiapoptotic activity of HDL by a mechanism requiring binding of apoE4 on VLDL particles to an LDL family receptor. This ability of APOE4/4 VLDL to inhibit the antiapoptotic effects of HDL presents a potential mechanism by which the expression of several diseases, including atherosclerosis, is enhanced by the APOE4 genotype.
- DeKroon, RM; Mihovilovic, M; Goodger, ZV; Robinette, JB; Sullivan, PM; Saunders, AM; Strittmatter, WJ
- August 2003
Volume / Issue
- 44 / 8
Start / End Page
- 1566 - 1573
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States