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Amyloid-beta1-42 reduces neuronal excitability in mouse dentate gyrus.

Publication ,  Journal Article
Yun, SH; Gamkrelidze, G; Stine, WB; Sullivan, PM; Pasternak, JF; Ladu, MJ; Trommer, BL
Published in: Neurosci Lett
July 31, 2006

Amyloid-beta (Abeta) is causally implicated in Alzheimer's disease and neuroplasticity failure has acquired validity as a possible mechanism of early AD pathogenesis. We have previously demonstrated that oligomeric Abeta(1-42) inhibits LTP in the dentate gyrus of rat hippocampal slices. We now show, using whole cell recordings in hippocampal granule cells, that oligomeric Abeta(1-42) decreases neuronal excitability. In particular, Abeta(1-42) application was associated with a decrease in the number of action potentials fired in response to current injection, and with an increase in the amplitude of the afterhyperpolarization. Reduced excitability may underlie the Abeta-mediated impairment in neuroplasticity, and ultimately may contribute to the memory loss in Alzheimer disease.

Duke Scholars

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

July 31, 2006

Volume

403

Issue

1-2

Start / End Page

162 / 165

Location

Ireland

Related Subject Headings

  • Peptide Fragments
  • Patch-Clamp Techniques
  • Neurons
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Long-Term Potentiation
  • In Vitro Techniques
  • Dentate Gyrus
  • Biopolymers
 

Citation

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Yun, S. H., Gamkrelidze, G., Stine, W. B., Sullivan, P. M., Pasternak, J. F., Ladu, M. J., & Trommer, B. L. (2006). Amyloid-beta1-42 reduces neuronal excitability in mouse dentate gyrus. Neurosci Lett, 403(1–2), 162–165. https://doi.org/10.1016/j.neulet.2006.04.065
Yun, Sung Hwan, Georgi Gamkrelidze, W Blaine Stine, Patrick M. Sullivan, Joseph F. Pasternak, Mary Jo Ladu, and Barbara L. Trommer. “Amyloid-beta1-42 reduces neuronal excitability in mouse dentate gyrus.Neurosci Lett 403, no. 1–2 (July 31, 2006): 162–65. https://doi.org/10.1016/j.neulet.2006.04.065.
Yun SH, Gamkrelidze G, Stine WB, Sullivan PM, Pasternak JF, Ladu MJ, et al. Amyloid-beta1-42 reduces neuronal excitability in mouse dentate gyrus. Neurosci Lett. 2006 Jul 31;403(1–2):162–5.
Yun, Sung Hwan, et al. “Amyloid-beta1-42 reduces neuronal excitability in mouse dentate gyrus.Neurosci Lett, vol. 403, no. 1–2, July 2006, pp. 162–65. Pubmed, doi:10.1016/j.neulet.2006.04.065.
Yun SH, Gamkrelidze G, Stine WB, Sullivan PM, Pasternak JF, Ladu MJ, Trommer BL. Amyloid-beta1-42 reduces neuronal excitability in mouse dentate gyrus. Neurosci Lett. 2006 Jul 31;403(1–2):162–165.
Journal cover image

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

July 31, 2006

Volume

403

Issue

1-2

Start / End Page

162 / 165

Location

Ireland

Related Subject Headings

  • Peptide Fragments
  • Patch-Clamp Techniques
  • Neurons
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Long-Term Potentiation
  • In Vitro Techniques
  • Dentate Gyrus
  • Biopolymers