ApoE isoform affects LTP in human targeted replacement mice.

Journal Article (Journal Article)

Inheritance of the epsilon4 allele for apolipoprotein E (apoE) increases the risk of Alzheimer disease and memory impairment, whereas epsilon2 decreases these risks compared with the most common epsilon3 allele, but the mechanism for these effects is unknown. Long-term potentiation (LTP) is an experimentally induced increase in synaptic efficacy that models memory. Using hippocampal slices from wild type (WT), apoE knockout (apoE-KO), and targeted replacement mice expressing human apoE2, E3, or E4 (apoE-TR) we found that although all strains had comparable basal synaptic transmission, LTP was significantly greater in WT and apoE3-TR than in apoE-KO, apoE2-TR or apoE4-TR. This novel system may be used to investigate the mechanisms of apoE isoform dependent modulation of susceptibility to memory impairment.

Full Text

Duke Authors

Cited Authors

  • Trommer, BL; Shah, C; Yun, SH; Gamkrelidze, G; Pasternak, ES; Ye, GL; Sotak, M; Sullivan, PM; Pasternak, JF; LaDu, MJ

Published Date

  • December 3, 2004

Published In

Volume / Issue

  • 15 / 17

Start / End Page

  • 2655 - 2658

PubMed ID

  • 15570172

International Standard Serial Number (ISSN)

  • 0959-4965

Digital Object Identifier (DOI)

  • 10.1097/00001756-200412030-00020


  • eng

Conference Location

  • England