ApoE isoform affects LTP in human targeted replacement mice.
Journal Article (Journal Article)
Inheritance of the epsilon4 allele for apolipoprotein E (apoE) increases the risk of Alzheimer disease and memory impairment, whereas epsilon2 decreases these risks compared with the most common epsilon3 allele, but the mechanism for these effects is unknown. Long-term potentiation (LTP) is an experimentally induced increase in synaptic efficacy that models memory. Using hippocampal slices from wild type (WT), apoE knockout (apoE-KO), and targeted replacement mice expressing human apoE2, E3, or E4 (apoE-TR) we found that although all strains had comparable basal synaptic transmission, LTP was significantly greater in WT and apoE3-TR than in apoE-KO, apoE2-TR or apoE4-TR. This novel system may be used to investigate the mechanisms of apoE isoform dependent modulation of susceptibility to memory impairment.
- Trommer, BL; Shah, C; Yun, SH; Gamkrelidze, G; Pasternak, ES; Ye, GL; Sotak, M; Sullivan, PM; Pasternak, JF; LaDu, MJ
- December 3, 2004
Volume / Issue
- 15 / 17
Start / End Page
- 2655 - 2658
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)