Detection of lung nodules on digital chest radiographs: potential usefulness of a new contralateral subtraction technique.


Journal Article

PURPOSE: To evaluate the potential usefulness of a contralateral subtraction technique developed for radiologists' performance in the detection of subtle lung nodules on chest radiographs. MATERIALS AND METHODS: Fifty chest radiographs (25 normal and 25 abnormal with a subtle lung nodule) that were digitized with a 0.175-mm pixel size and 4,096 gray levels were used. Twelve radiologists (10 attending and two residents) participated in observer tests and read both original and contralateral subtraction images with a sequential testing method. Radiologists' performance was evaluated by means of receiver operating characteristic analysis with use of a continuous rating scale. The beneficial and detrimental effects of the contralateral subtraction technique on the radiologists' performance were also evaluated. RESULTS: The area under the receiver operating characteristic curve values obtained without and with contralateral subtraction images were 0.926 and 0.962, respectively. Results indicated that the contralateral subtraction images significantly (P <.05) improved diagnostic accuracy, particularly for radiologists with limited experience. CONCLUSION: The contralateral subtraction technique can assist radiologists in the correct identification of subtle lung nodules on chest radiographs.

Full Text

Duke Authors

Cited Authors

  • Tsukuda, S; Heshiki, A; Katsuragawa, S; Li, Q; MacMahon, H; Doi, K

Published Date

  • April 2002

Published In

Volume / Issue

  • 223 / 1

Start / End Page

  • 199 - 203

PubMed ID

  • 11930067

Pubmed Central ID

  • 11930067

International Standard Serial Number (ISSN)

  • 0033-8419

Digital Object Identifier (DOI)

  • 10.1148/radiol.2231010344


  • eng

Conference Location

  • United States