Computer-aided diagnostic scheme for lung nodule detection in digital chest radiographs by use of a multiple-template matching technique.


Journal Article

We have been developing a computer-aided diagnostic (CAD) scheme to assist radiologists in improving the detection of pulmonary nodules in chest radiographs, because radiologists can miss as many as 30% of pulmonary nodules in routine clinical practice. A key to the successful clinical application of a CAD scheme is to ensure that there are only a small number of false positives that are incorrectly reported as nodules by the scheme. In order to significantly reduce the number of false positives in our CAD scheme, we developed, in this study, a multiple-template matching technique, in which a test candidate can be identified as a false positive and thus eliminated, if its largest cross-correlation value with non-nodule templates is larger than that with nodule templates. We describe the technique for determination of cross-correlation values for test candidates with nodule templates and non-nodule templates, the technique for creation of a large number of nodule templates and non-nodule templates, and the technique for removal of nodulelike non-nodule templates and non-nodulelike nodule templates, in order to achieve a good performance. In our study, a large number of false positives (44.3%) were removed with reduction of a very small number of true positives (2.3%) by use of the multiple-template matching technique. We believe that this technique can be used to significantly improve the performance of CAD schemes for lung nodule detection in chest radiographs.

Full Text

Duke Authors

Cited Authors

  • Li, Q; Katsuragawa, S; Doi, K

Published Date

  • October 1, 2001

Published In

Volume / Issue

  • 28 / 10

Start / End Page

  • 2070 - 2076

PubMed ID

  • 11695768

Pubmed Central ID

  • 11695768

International Standard Serial Number (ISSN)

  • 0094-2405

Digital Object Identifier (DOI)

  • 10.1118/1.1406517


  • eng

Conference Location

  • United States