Computerized detection of lung nodules in thin-section CT images by use of selective enhancement filters and an automated rule-based classifier.


Journal Article

RATIONALE AND OBJECTIVES: We have been developing a computer-aided diagnostic (CAD) scheme for lung nodule detection in order to assist radiologists in the detection of lung cancer in thin-section computed tomography (CT) images. MATERIALS AND METHODS: Our database consisted of 117 thin-section CT scans with 153 nodules, obtained from a lung cancer screening program at a Japanese university (85 scans, 91 nodules) and from clinical work at an American university (32 scans, 62 nodules). The database included nodules of different sizes (4-28 mm, mean 10.2 mm), shapes, and patterns (solid and ground-glass opacity (GGO)). Our CAD scheme consisted of modules for lung segmentation, selective nodule enhancement, initial nodule detection, feature extraction, and classification. The selective nodule enhancement filter was a key technique for significant enhancement of nodules and suppression of normal anatomic structures such as blood vessels, which are the main sources of false positives. Use of an automated rule-based classifier for reduction of false positives was another key technique; it resulted in a minimized overtraining effect and an improved classification performance. We used a case-based four-fold cross-validation testing method for evaluation of the performance levels of our computerized detection scheme. RESULTS: Our CAD scheme achieved an overall sensitivity of 86% (small: 76%, medium-sized: 94%, large: 95%; solid: 86%, mixed GGO: 89%, pure GGO: 81%) with 6.6 false positives per scan; an overall sensitivity of 81% (small: 69%, medium-sized: 91%, large: 91%; solid: 79%, mixed GGO: 88%, pure GGO: 81%) with 3.3 false positives per scan; and an overall sensitivity of 75% (small: 60%, medium-sized: 88%, large: 87%; solid: 70%, mixed GGO: 87%, pure GGO: 81%) with 1.6 false positives per scan. CONCLUSION: The experimental results indicate that our CAD scheme with its two key techniques can achieve a relatively high performance for nodules presenting large variations in size, shape, and pattern.

Full Text

Duke Authors

Cited Authors

  • Li, Q; Li, F; Doi, K

Published Date

  • February 2008

Published In

Volume / Issue

  • 15 / 2

Start / End Page

  • 165 - 175

PubMed ID

  • 18206615

Pubmed Central ID

  • 18206615

International Standard Serial Number (ISSN)

  • 1076-6332

Digital Object Identifier (DOI)

  • 10.1016/j.acra.2007.09.018


  • eng

Conference Location

  • United States