Iris vasculopathy in exfoliation syndrome. An immunocytochemical study.

Journal Article (Journal Article)

Samples of control iris tissue obtained from seven enucleated eyes and nine exfoliative iridectomy specimens were prepared for an immunocytochemical study of the matrix in the walls of iris vessels. The distribution of collagen types I, IV and laminin was studied in normal and exfoliative vessels. Laminin was an integral component of exfoliation material and was present mainly in the matrix of the outer surface of normal vascular cohort cells. The laminin content in the latter location was reduced in vessels in which exfoliation aggregates were not visible. Collagen type IV was absent from exfoliation material. While type I was present in the deposits, it was considered to represent a residue of native normal tissue. Exfoliation deposits appeared to stimulate the synthesis of collagen types I and IV at an early stage of the disease.

Full Text

Duke Authors

Cited Authors

  • Konstas, AG; Marshall, GE; Lee, WR

Published Date

  • August 1991

Published In

Volume / Issue

  • 69 / 4

Start / End Page

  • 472 - 483

PubMed ID

  • 1750316

International Standard Serial Number (ISSN)

  • 0001-639X

Digital Object Identifier (DOI)

  • 10.1111/j.1755-3768.1991.tb02025.x


  • eng

Conference Location

  • Denmark