Nonemergency use of slow infusions of diazoxide.

Journal Article (Clinical Trial;Journal Article)

Slow infusions of diazoxide were administered to 10 hypertensive patients who had stable, nonaccelerated hypertension. The 10-min diazoxide infusion was associated with a 16% average reduction in arterial pressure, a 21% average increase in heart rate, a 16% average increase in cardiac output, and a 36% reduction in total peripheral resistance. These changes in hemodynamic parameters lasted for an average of 70 min. It was concluded that slow infusions of diazoxide produce a consistent and predictable antihypertensive effect in patients with stable, nonaccelerated hypertension. Slow infusions of diazoxide may have a limited use in nonemergency situations where an abrupt change in arterial pressure is to be avoided and a parenteral antihypertensive agent is needed.

Full Text

Duke Authors

Cited Authors

  • Lee, WR; Mroczek, WJ; Davidov, ME; Finnerty, FS

Published Date

  • August 1, 1975

Published In

Volume / Issue

  • 18 / 2

Start / End Page

  • 154 - 157

PubMed ID

  • 1097151

International Standard Serial Number (ISSN)

  • 0009-9236

Digital Object Identifier (DOI)

  • 10.1002/cpt1975182154


  • eng

Conference Location

  • United States