The pathology of vitreous hemorrhage. II. Ultrastructure.
Journal Article (Journal Article)
We undertook an ultrastructural study of the dual processes of hemolysis and vitreous membrane formation during the resolution of vitreous blood clots in rabbits. Red blood cell degradation began within 24 hours before the onset of the inflammatory response and occurred mainly in the extracellular matrix. Macrophage activity was directed at clearing lysed RBC debris, rather than engulfing whole RBCs. Hemolysis in the vitreous may have been initiated by the unfavorable microenvironment. Two types of vitreous membranes occurred during vitreous clot lysis. Cellular membranes were composed of aggregates of giant macrophages enclosed within a thin collagen sheet. Acellular membranes developed from coaggregated vitreous collagen fibers. A prominent acellular membrane surrounded the blood clot as a pseudocapsule. No fibroblasts or fresh collagen deposition were observed.
Full Text
Duke Authors
Cited Authors
- Forrester, JV; Grierson, I; Lee, WR
Published Date
- December 1979
Published In
Volume / Issue
- 97 / 12
Start / End Page
- 2368 - 2374
PubMed ID
- 518391
International Standard Serial Number (ISSN)
- 0003-9950
Digital Object Identifier (DOI)
- 10.1001/archopht.1979.01020020584018
Language
- eng
Conference Location
- United States