Pressure-induced changes in the ultrastructure of the endothelium lining Schlemm's canal.
Journal Article (Journal Article)
In a transmission electron microscopic investigation of the endothelium lining Schlemm's canal subjected to graded levels of intraocular pressure (0 to 50 mm Hg for one hour), there was an increase in the number of vacuolar structures with the increase in pressure (range, 8 to 30 mm Hg). At 0 mm Hg, giant vacuoles were absent, while at 50 mm Hg their numbers were less than at 22 and 30 mm Hg. Vacuoles were invaginations either from the meshwork or from the canal surface of the endothelium. A few were transcellular channels that possibly served as a pressure-sensitive outflow system. In addition, the numbers of nonvacuolar transcellular channels and minipores increased with an increase in pressure while the numbers of pinocytotic and micropinocytotic vesicles decreased. The changes were not accompanied by alterations in organelles associated either with protein or energy production. At 50 mm Hg, breaches in the endothelium lining the trabecular wall were obvious and aqueous outflow was considered to be by nonphysiologic routes.
Full Text
Duke Authors
Cited Authors
- Grierson, I; Lee, WR
Published Date
- November 1, 1975
Published In
Volume / Issue
- 80 / 5
Start / End Page
- 863 - 884
PubMed ID
- 811121
International Standard Serial Number (ISSN)
- 0002-9394
Digital Object Identifier (DOI)
- 10.1016/0002-9394(75)90284-6
Language
- eng
Conference Location
- United States