Microvilli elongate in response to hydrogen peroxide and to perturbations of intracellular calcium.

Journal Article

Using scanning electron microscopy and fluorescence microscopy, we have found that apical microvilli of diverse cell types, including nonepithelial cells, elongate in culture in response to the oxidative stress of hydrogen peroxide. The microvilli induced in culture on retinal pigment epithelial cells display a 30-nm axial periodicity similar to that described for stable microvilli of intestinal brush border. Microvilli can also be induced to elongate by chelating intracellular Ca2+ and by the Ca(2+)-uptake inhibitor thapsigargin. Thus a response of microvillar protrusion occurs widely and may be related to depletion of intracellular calcium stores.

Full Text

Duke Authors

Cited Authors

  • Reid, GG; Edwards, JG; Marshall, GE; Sutcliffe, RG; Lee, WR

Published Date

  • October 10, 1997

Published In

Volume / Issue

  • 236 / 1

Start / End Page

  • 86 - 93

PubMed ID

  • 9344588

Pubmed Central ID

  • 9344588

International Standard Serial Number (ISSN)

  • 0014-4827

Digital Object Identifier (DOI)

  • 10.1006/excr.1997.3701

Language

  • eng

Conference Location

  • United States