Congenital toxoplasmic retinochoroiditis in a mouse model.

Journal Article (Journal Article)

A study of the eyes of adult mice infected in utero with Toxoplasma gondii is reported. The histopathological features of the ocular inflammatory response in the infected mice ranged from minimal damage to complete destruction of the retinal tissue. Notable features such as retinal vasculitis and an almost uniform and highly selective destruction of the photoreceptor layer of the retina suggest a similarity between experimental autoimmune retinitis and the disease process in the retinas of our Toxoplasma-infected mice. We suggest that our mouse model could provide a simple and inexpensive tool for the investigation of immuno-pathological processes in the retina resulting from congenital Toxoplasma infection. The model has the advantage of low post-natal mortality coupled with high ocular morbidity. Furthermore, its aetiology is probably analogous to that of human ocular toxoplasmosis, in that the foetus becomes infected in utero via a mother whose primary infection is acquired during gestation.

Full Text

Duke Authors

Cited Authors

  • Hay, J; Lee, WR; Dutton, GN; Hutchison, WM; Siim, JC

Published Date

  • April 1984

Published In

Volume / Issue

  • 78 / 2

Start / End Page

  • 109 - 116

PubMed ID

  • 6742924

International Standard Serial Number (ISSN)

  • 0003-4983

Digital Object Identifier (DOI)

  • 10.1080/00034983.1984.11811784

Language

  • eng

Conference Location

  • England