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Congenital toxoplasmic retinochoroiditis in a mouse model.

Publication ,  Journal Article
Hay, J; Lee, WR; Dutton, GN; Hutchison, WM; Siim, JC
Published in: Annals of tropical medicine and parasitology
April 1984

A study of the eyes of adult mice infected in utero with Toxoplasma gondii is reported. The histopathological features of the ocular inflammatory response in the infected mice ranged from minimal damage to complete destruction of the retinal tissue. Notable features such as retinal vasculitis and an almost uniform and highly selective destruction of the photoreceptor layer of the retina suggest a similarity between experimental autoimmune retinitis and the disease process in the retinas of our Toxoplasma-infected mice. We suggest that our mouse model could provide a simple and inexpensive tool for the investigation of immuno-pathological processes in the retina resulting from congenital Toxoplasma infection. The model has the advantage of low post-natal mortality coupled with high ocular morbidity. Furthermore, its aetiology is probably analogous to that of human ocular toxoplasmosis, in that the foetus becomes infected in utero via a mother whose primary infection is acquired during gestation.

Published In

Annals of tropical medicine and parasitology

ISSN

0003-4983

Publication Date

April 1984

Volume

78

Issue

2

Start / End Page

109 / 116

Location

england

Related Subject Headings

  • Tropical Medicine
  • Toxoplasmosis, Ocular
  • Toxoplasmosis, Animal
  • Retina
  • Mice
  • Disease Models, Animal
  • Choroid
  • Chorioretinitis
  • Animals
  • 4206 Public health
 

Citation

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Hay, J., Lee, W. R., Dutton, G. N., Hutchison, W. M., & Siim, J. C. (1984). Congenital toxoplasmic retinochoroiditis in a mouse model. Annals of Tropical Medicine and Parasitology, 78(2), 109–116.
Hay, J., W. R. Lee, G. N. Dutton, W. M. Hutchison, and J. C. Siim. “Congenital toxoplasmic retinochoroiditis in a mouse model.Annals of Tropical Medicine and Parasitology 78, no. 2 (April 1984): 109–16.
Hay J, Lee WR, Dutton GN, Hutchison WM, Siim JC. Congenital toxoplasmic retinochoroiditis in a mouse model. Annals of tropical medicine and parasitology. 1984 Apr;78(2):109–16.
Hay, J., et al. “Congenital toxoplasmic retinochoroiditis in a mouse model.Annals of Tropical Medicine and Parasitology, vol. 78, no. 2, Apr. 1984, pp. 109–16.
Hay J, Lee WR, Dutton GN, Hutchison WM, Siim JC. Congenital toxoplasmic retinochoroiditis in a mouse model. Annals of tropical medicine and parasitology. 1984 Apr;78(2):109–116.

Published In

Annals of tropical medicine and parasitology

ISSN

0003-4983

Publication Date

April 1984

Volume

78

Issue

2

Start / End Page

109 / 116

Location

england

Related Subject Headings

  • Tropical Medicine
  • Toxoplasmosis, Ocular
  • Toxoplasmosis, Animal
  • Retina
  • Mice
  • Disease Models, Animal
  • Choroid
  • Chorioretinitis
  • Animals
  • 4206 Public health