Role of conserved gp41 cysteine residues in the processing of human immunodeficiency virus envelope precursor and viral infectivity.

Published

Journal Article (Academic article)

All animal retroviruses whose nucleotide sequences have been determined contain two or three closely spaced cysteine residues in the extracellular domain of the env-encoded transmembrane protein. Using human immunodeficiency virus type 1 gp41 as a working model, the functional significance of these highly conserved cysteines was investigated. We report here that substituting the two conserved cysteine residues in this domain of gp41 with glycine residues resulted in the loss of viral infectivity, which could be attributed to severe impairment in the processing of gp160 precursor to gp120.

Duke Authors

Cited Authors

  • Syu, WJ; Lee, WR; Du, B; Yu, QC; Essex, M; Lee, TH

Published Date

  • November 1991

Published In

Volume / Issue

  • 65 / 11

Start / End Page

  • 6349 - 6352

International Standard Serial Number (ISSN)

  • 0022-538X

Conference Location

  • united states