Addition of molecular methods to mutation studies with Drosophila melanogaster.

Journal Article (Journal Article;Review)

For 80 years, Drosophila melanogaster has been used as a major tool in analyzing Mendelian genetics. By using chromosome inversions that suppress crossing over, geneticists have developed a large number of stocks for mutation analysis. These stocks permit numerous tests for specific locus mutations, lethals at multiple loci on any chromosome, chromosome exchanges, insertions, and deletions. The entire genome can be manipulated for a degree of genetic control not found in other germ-line systems. Recombinant DNA techniques now permit analysis of mutations to the nucleotide level. By combining classical genetic analysis with recombinant DNA techniques, it is possible to analyze mutations that range from chromosome aberrations and multilocus deficiencies to single nucleotide transitions.

Full Text

Duke Authors

Cited Authors

  • Lee, WR

Published Date

  • 1989

Published In

Volume / Issue

  • 14 Suppl 16 /

Start / End Page

  • 99 - 104

PubMed ID

  • 2499453

International Standard Serial Number (ISSN)

  • 0893-6692

Digital Object Identifier (DOI)

  • 10.1002/em.2850140618

Language

  • eng

Conference Location

  • United States