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RTOG GU Radiation oncology specialists reach consensus on pelvic lymph node volumes for high-risk prostate cancer.

Publication ,  Journal Article
Lawton, CAF; Michalski, J; El-Naqa, I; Buyyounouski, MK; Lee, WR; Menard, C; O'Meara, E; Rosenthal, SA; Ritter, M; Seider, M
Published in: Int J Radiat Oncol Biol Phys
June 1, 2009

PURPOSE: Radiation therapy to the pelvic lymph nodes in high-risk prostate cancer is required on several Radiation Therapy Oncology Group (RTOG) clinical trials. Based on a prior lymph node contouring project, we have shown significant disagreement in the definition of pelvic lymph node volumes among genitourinary radiation oncology specialists involved in developing and executing current RTOG trials. MATERIALS AND METHODS: A consensus meeting was held on October 3, 2007, to reach agreement on pelvic lymph node volumes. Data were presented to address the lymph node drainage of the prostate. Extensive discussion ensued to develop clinical target volume (CTV) pelvic lymph node consensus. RESULTS: Consensus was obtained resulting in computed tomography image-based pelvic lymph node CTVs. Based on this consensus, the pelvic lymph node volumes to be irradiated include: distal common iliac, presacral lymph nodes (S(1)-S(3)), external iliac lymph nodes, internal iliac lymph nodes, and obturator lymph nodes. Lymph node CTVs include the vessels (artery and vein) and a 7-mm radial margin being careful to "carve out" bowel, bladder, bone, and muscle. Volumes begin at the L5/S1 interspace and end at the superior aspect of the pubic bone. Consensus on dose-volume histogram constraints for OARs was also attained. CONCLUSIONS: Consensus on pelvic lymph node CTVs for radiation therapy to address high-risk prostate cancer was attained and is available as web-based computed tomography images as well as a descriptive format through the RTOG. This will allow for uniformity in evaluating the benefit and risk of such treatment.

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Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

June 1, 2009

Volume

74

Issue

2

Start / End Page

383 / 387

Location

United States

Related Subject Headings

  • Urology
  • Urinary Bladder
  • Tomography, X-Ray Computed
  • Rectum
  • Radiotherapy Dosage
  • Radiation Oncology
  • Prostatic Neoplasms
  • Pelvis
  • Oncology & Carcinogenesis
  • Male
 

Citation

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Lawton, C. A. F., Michalski, J., El-Naqa, I., Buyyounouski, M. K., Lee, W. R., Menard, C., … Seider, M. (2009). RTOG GU Radiation oncology specialists reach consensus on pelvic lymph node volumes for high-risk prostate cancer. Int J Radiat Oncol Biol Phys, 74(2), 383–387. https://doi.org/10.1016/j.ijrobp.2008.08.002
Lawton, Colleen A. F., Jeff Michalski, Issam El-Naqa, Mark K. Buyyounouski, W Robert Lee, Cynthia Menard, Elizabeth O’Meara, Seth A. Rosenthal, Mark Ritter, and Michael Seider. “RTOG GU Radiation oncology specialists reach consensus on pelvic lymph node volumes for high-risk prostate cancer.Int J Radiat Oncol Biol Phys 74, no. 2 (June 1, 2009): 383–87. https://doi.org/10.1016/j.ijrobp.2008.08.002.
Lawton CAF, Michalski J, El-Naqa I, Buyyounouski MK, Lee WR, Menard C, et al. RTOG GU Radiation oncology specialists reach consensus on pelvic lymph node volumes for high-risk prostate cancer. Int J Radiat Oncol Biol Phys. 2009 Jun 1;74(2):383–7.
Lawton, Colleen A. F., et al. “RTOG GU Radiation oncology specialists reach consensus on pelvic lymph node volumes for high-risk prostate cancer.Int J Radiat Oncol Biol Phys, vol. 74, no. 2, June 2009, pp. 383–87. Pubmed, doi:10.1016/j.ijrobp.2008.08.002.
Lawton CAF, Michalski J, El-Naqa I, Buyyounouski MK, Lee WR, Menard C, O’Meara E, Rosenthal SA, Ritter M, Seider M. RTOG GU Radiation oncology specialists reach consensus on pelvic lymph node volumes for high-risk prostate cancer. Int J Radiat Oncol Biol Phys. 2009 Jun 1;74(2):383–387.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

June 1, 2009

Volume

74

Issue

2

Start / End Page

383 / 387

Location

United States

Related Subject Headings

  • Urology
  • Urinary Bladder
  • Tomography, X-Ray Computed
  • Rectum
  • Radiotherapy Dosage
  • Radiation Oncology
  • Prostatic Neoplasms
  • Pelvis
  • Oncology & Carcinogenesis
  • Male