Laryngeal and ocular granulation tissue formation in two Punjabi children: LOGIC syndrome.

Journal Article (Journal Article)

Two unrelated children, both born in the United Kingdom of Punjabi Muslim parents, developed within months of birth, nodules in the larynx, conjunctiva and nailbeds. Currently the younger female child, aged five, is developing skin papules while the elder boy, now aged 15, is debilitated by oral, oesophageal and tracheal granulation tissue formation. Numerous biopsies of the affected tissues have revealed subepithelial granulation tissue formation of unknown aetiology. Extensive haematological, biochemical and bacteriological investigations were uninformative as to the cause. Treatment with steroids, dapsone, antituberculous drugs, and local excision failed to control the disease. No description of this condition exists in the international medical literature available to us.

Full Text

Duke Authors

Cited Authors

  • Ainsworth, JR; Spencer, AF; Dudgeon, J; Geddes, NK; Lee, WR

Published Date

  • 1991

Published In

Volume / Issue

  • 5 ( Pt 6) /

Start / End Page

  • 717 - 722

PubMed ID

  • 1800173

International Standard Serial Number (ISSN)

  • 0950-222X

Digital Object Identifier (DOI)

  • 10.1038/eye.1991.132


  • eng

Conference Location

  • England