B-lymphocytes from melanoma patients and normal individuals react with melanoma cells but also with irrelevant antigens.
Publication
, Journal Article
Damato, BE; Campbell, AM; McGuire, BJ; Lee, WR; Foulds, WS
Published in: Br J Cancer
August 1988
Peripheral B-lymphocytes of 13 patients with uveal melanoma and of 5 healthy individuals were transformed with Epstein-Barr virus (EBV). The reactivity of these transformed cells with autologous or allogeneic melanoma cells and lymphocytes was measured by the enzyme-linked immunosorbent assay (ELISA). Antigens which are neither self nor common environmental antigens (i.e., plant protoplasts, schistosome antigen and keyhole limpet haemocyanin) were used for controls. Lymphocyte reactivity with all types of antigen was apparent both in patients with uveal melanoma and in normal controls. The response detected by the techniques available is likely to reflect antibody multispecificity leading to mis-identification of irrelevant antigens.
Duke Scholars
Published In
Br J Cancer
DOI
ISSN
0007-0920
Publication Date
August 1988
Volume
58
Issue
2
Start / End Page
182 / 185
Location
England
Related Subject Headings
- Uveal Neoplasms
- Schistosoma mansoni
- Protoplasts
- Oncology & Carcinogenesis
- Melanoma
- Humans
- Hemocyanins
- Enzyme-Linked Immunosorbent Assay
- Cell Transformation, Viral
- B-Lymphocytes
Citation
APA
Chicago
ICMJE
MLA
NLM
Damato, B. E., Campbell, A. M., McGuire, B. J., Lee, W. R., & Foulds, W. S. (1988). B-lymphocytes from melanoma patients and normal individuals react with melanoma cells but also with irrelevant antigens. Br J Cancer, 58(2), 182–185. https://doi.org/10.1038/bjc.1988.188
Damato, B. E., A. M. Campbell, B. J. McGuire, W. R. Lee, and W. S. Foulds. “B-lymphocytes from melanoma patients and normal individuals react with melanoma cells but also with irrelevant antigens.” Br J Cancer 58, no. 2 (August 1988): 182–85. https://doi.org/10.1038/bjc.1988.188.
Damato BE, Campbell AM, McGuire BJ, Lee WR, Foulds WS. B-lymphocytes from melanoma patients and normal individuals react with melanoma cells but also with irrelevant antigens. Br J Cancer. 1988 Aug;58(2):182–5.
Damato, B. E., et al. “B-lymphocytes from melanoma patients and normal individuals react with melanoma cells but also with irrelevant antigens.” Br J Cancer, vol. 58, no. 2, Aug. 1988, pp. 182–85. Pubmed, doi:10.1038/bjc.1988.188.
Damato BE, Campbell AM, McGuire BJ, Lee WR, Foulds WS. B-lymphocytes from melanoma patients and normal individuals react with melanoma cells but also with irrelevant antigens. Br J Cancer. 1988 Aug;58(2):182–185.
Published In
Br J Cancer
DOI
ISSN
0007-0920
Publication Date
August 1988
Volume
58
Issue
2
Start / End Page
182 / 185
Location
England
Related Subject Headings
- Uveal Neoplasms
- Schistosoma mansoni
- Protoplasts
- Oncology & Carcinogenesis
- Melanoma
- Humans
- Hemocyanins
- Enzyme-Linked Immunosorbent Assay
- Cell Transformation, Viral
- B-Lymphocytes