Uveal melanoma: updated considerations on current management modalities.

Journal Article (Journal Article;Review)

Published data on growth rates of uveal melanomas and effects of treatment modalities raise important considerations. Dissemination from uveal melanomas starts after the tumour is larger than 7 mm diameter; growth from 7 to 10 mm diameter increases the risk of metastases incrementally to approximately 16%. Estimations of tumour doubling times indicate that metastatic death before 8 years is nearly always due to pre-therapeutic dissemination so that the impact on survival by therapy can only be assessed thereafter. Histopathology on irradiated melanomas reveals that reproductive activity has not been suppressed and the anticipated (and unfavourable) risk of metastases is not balanced by poor post-irradiation visual acuity. Also the psychological well-being of a patient with a functional fellow eye is better after primary enucleation. Conservative management is most appropriate for: small melanomas, patients with a short life expectancy, melanomas in a single functioning eye, and patients refusing enucleation.

Full Text

Duke Authors

Cited Authors

  • Manschot, WA; Lee, WR; van Strik, R

Published Date

  • 1995

Published In

Volume / Issue

  • 19 / 4

Start / End Page

  • 203 - 209

PubMed ID

  • 8737700

International Standard Serial Number (ISSN)

  • 0165-5701

Digital Object Identifier (DOI)

  • 10.1007/BF00132688


  • eng

Conference Location

  • Netherlands