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Uveal melanoma: updated considerations on current management modalities.

Publication ,  Journal Article
Manschot, WA; Lee, WR; van Strik, R
Published in: Int Ophthalmol
1995

Published data on growth rates of uveal melanomas and effects of treatment modalities raise important considerations. Dissemination from uveal melanomas starts after the tumour is larger than 7 mm diameter; growth from 7 to 10 mm diameter increases the risk of metastases incrementally to approximately 16%. Estimations of tumour doubling times indicate that metastatic death before 8 years is nearly always due to pre-therapeutic dissemination so that the impact on survival by therapy can only be assessed thereafter. Histopathology on irradiated melanomas reveals that reproductive activity has not been suppressed and the anticipated (and unfavourable) risk of metastases is not balanced by poor post-irradiation visual acuity. Also the psychological well-being of a patient with a functional fellow eye is better after primary enucleation. Conservative management is most appropriate for: small melanomas, patients with a short life expectancy, melanomas in a single functioning eye, and patients refusing enucleation.

Duke Scholars

Published In

Int Ophthalmol

DOI

ISSN

0165-5701

Publication Date

1995

Volume

19

Issue

4

Start / End Page

203 / 209

Location

Netherlands

Related Subject Headings

  • Uveal Neoplasms
  • Survival Rate
  • Ophthalmology & Optometry
  • Melanoma
  • Humans
  • Combined Modality Therapy
  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry
 

Citation

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Manschot, W. A., Lee, W. R., & van Strik, R. (1995). Uveal melanoma: updated considerations on current management modalities. Int Ophthalmol, 19(4), 203–209. https://doi.org/10.1007/BF00132688
Manschot, W. A., W. R. Lee, and R. van Strik. “Uveal melanoma: updated considerations on current management modalities.Int Ophthalmol 19, no. 4 (1995): 203–9. https://doi.org/10.1007/BF00132688.
Manschot WA, Lee WR, van Strik R. Uveal melanoma: updated considerations on current management modalities. Int Ophthalmol. 1995;19(4):203–9.
Manschot, W. A., et al. “Uveal melanoma: updated considerations on current management modalities.Int Ophthalmol, vol. 19, no. 4, 1995, pp. 203–09. Pubmed, doi:10.1007/BF00132688.
Manschot WA, Lee WR, van Strik R. Uveal melanoma: updated considerations on current management modalities. Int Ophthalmol. 1995;19(4):203–209.
Journal cover image

Published In

Int Ophthalmol

DOI

ISSN

0165-5701

Publication Date

1995

Volume

19

Issue

4

Start / End Page

203 / 209

Location

Netherlands

Related Subject Headings

  • Uveal Neoplasms
  • Survival Rate
  • Ophthalmology & Optometry
  • Melanoma
  • Humans
  • Combined Modality Therapy
  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry