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Experimental ocular toxocariasis: a mouse model.

Publication ,  Journal Article
Ghafoor, SY; Smith, HV; Lee, WR; Quinn, R; Girdwood, RW
Published in: The British journal of ophthalmology
February 1984

Male mice, strain C57 black, were infected with Toxocara canis by a single intragastric dose of 1500 infective eggs. The eyes were studied at sequential time periods after infection (6 to 63 days) by conventional microscopic techniques, and the histological characteristics of the inflammatory response were recorded. In the majority of animals the disease was unilateral. Twenty-six larvae were found in the retina, in the retinal vessels, and in the subretinal space in 20 eyes, while in 29 eyes there were inflammatory changes which were not related to the presence of intact or fragmented larval forms. The inflammatory reaction began as a polymorphonuclear response but after day 13 became a granulomatous reaction. This suggests that the inflammatory phenomenon may be propagated by the secreted surface antigens in the absence of the living or dead larvae.

Published In

The British journal of ophthalmology

ISSN

0007-1161

Publication Date

February 1984

Volume

68

Issue

2

Start / End Page

89 / 96

Location

england

Related Subject Headings

  • Toxocariasis
  • Toxocara
  • Retina
  • Ophthalmology & Optometry
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Granuloma
  • Eye Diseases
  • Eye
 

Citation

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ICMJE
MLA
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Ghafoor, S. Y., Smith, H. V., Lee, W. R., Quinn, R., & Girdwood, R. W. (1984). Experimental ocular toxocariasis: a mouse model. The British Journal of Ophthalmology, 68(2), 89–96.
Ghafoor, S. Y., H. V. Smith, W. R. Lee, R. Quinn, and R. W. Girdwood. “Experimental ocular toxocariasis: a mouse model.The British Journal of Ophthalmology 68, no. 2 (February 1984): 89–96.
Ghafoor SY, Smith HV, Lee WR, Quinn R, Girdwood RW. Experimental ocular toxocariasis: a mouse model. The British journal of ophthalmology. 1984 Feb;68(2):89–96.
Ghafoor, S. Y., et al. “Experimental ocular toxocariasis: a mouse model.The British Journal of Ophthalmology, vol. 68, no. 2, Feb. 1984, pp. 89–96.
Ghafoor SY, Smith HV, Lee WR, Quinn R, Girdwood RW. Experimental ocular toxocariasis: a mouse model. The British journal of ophthalmology. 1984 Feb;68(2):89–96.

Published In

The British journal of ophthalmology

ISSN

0007-1161

Publication Date

February 1984

Volume

68

Issue

2

Start / End Page

89 / 96

Location

england

Related Subject Headings

  • Toxocariasis
  • Toxocara
  • Retina
  • Ophthalmology & Optometry
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Granuloma
  • Eye Diseases
  • Eye