Extreme hypofractionation for prostate cancer.

Journal Article (Journal Article)

In ideal circumstances the fractionation schedule of radiotherapy should match the fractionation sensitivity of the tumor relative to the nearby normal tissues. A number of recent publications have suggested that the alpha/beta ratio for prostate tumors is low - in the range of 1-3 Gy. In fact, if alpha/beta is low, then hypofractionated schedules using fewer, larger fractions should improve the therapeutic ratio. This critical article examines two methods that represent schedules at the extreme end of the fractionation spectrum (3-5 fractions): high-dose-rate brachytherapy as monotherapy and stereotactic body radiotherapy.

Full Text

Duke Authors

Cited Authors

  • Lee, WR

Published Date

  • January 2009

Published In

Volume / Issue

  • 9 / 1

Start / End Page

  • 61 - 65

PubMed ID

  • 19105707

Electronic International Standard Serial Number (EISSN)

  • 1744-8328

Digital Object Identifier (DOI)

  • 10.1586/14737140.9.1.61


  • eng

Conference Location

  • England