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In vivo bone lead measurements: a rapid monitoring method for cumulative lead exposure.

Publication ,  Journal Article
Wielopolski, L; Ellis, KJ; Vaswani, AN; Cohn, SH; Greenberg, A; Puschett, JB; Parkinson, DK; Fetterolf, DE; Landrigan, PJ
Published in: Am J Ind Med
1986

Lead concentrations (microgram/g wet weight) in human bone (tibia) were measured noninvasively in vivo employing an X-ray fluorescence technique. Forty-five workers who had been subjected to chronic industrial exposure were found to have a mean bone lead content of 52.9 micrograms/g wet weight (0 to 198 micrograms/g). In addition to bone lead content, blood lead, body burden of lead as assessed by urinary lead excretion after EDTA chelation, zinc protoporphyrin, and unstimulated urinary lead excretion were evaluated. The results suggest that the in vivo measurement of tibia lead content may serve as an acceptable indicator of body lead burden and provide a practical technique for lead screening purposes. The correlation coefficient between X-ray fluorescence findings and lead excretion following Ca-EDTA administration is 0.69; p less than 0.001.

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Published In

Am J Ind Med

DOI

ISSN

0271-3586

Publication Date

1986

Volume

9

Issue

3

Start / End Page

221 / 226

Location

United States

Related Subject Headings

  • X-Rays
  • Radiography
  • Occupational Diseases
  • Male
  • Lead
  • Humans
  • Fluorescence
  • Environmental Exposure
  • Environmental & Occupational Health
  • Bone and Bones
 

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Wielopolski, L., Ellis, K. J., Vaswani, A. N., Cohn, S. H., Greenberg, A., Puschett, J. B., … Landrigan, P. J. (1986). In vivo bone lead measurements: a rapid monitoring method for cumulative lead exposure. Am J Ind Med, 9(3), 221–226. https://doi.org/10.1002/ajim.4700090304
Wielopolski, L., K. J. Ellis, A. N. Vaswani, S. H. Cohn, A. Greenberg, J. B. Puschett, D. K. Parkinson, D. E. Fetterolf, and P. J. Landrigan. “In vivo bone lead measurements: a rapid monitoring method for cumulative lead exposure.Am J Ind Med 9, no. 3 (1986): 221–26. https://doi.org/10.1002/ajim.4700090304.
Wielopolski L, Ellis KJ, Vaswani AN, Cohn SH, Greenberg A, Puschett JB, et al. In vivo bone lead measurements: a rapid monitoring method for cumulative lead exposure. Am J Ind Med. 1986;9(3):221–6.
Wielopolski, L., et al. “In vivo bone lead measurements: a rapid monitoring method for cumulative lead exposure.Am J Ind Med, vol. 9, no. 3, 1986, pp. 221–26. Pubmed, doi:10.1002/ajim.4700090304.
Wielopolski L, Ellis KJ, Vaswani AN, Cohn SH, Greenberg A, Puschett JB, Parkinson DK, Fetterolf DE, Landrigan PJ. In vivo bone lead measurements: a rapid monitoring method for cumulative lead exposure. Am J Ind Med. 1986;9(3):221–226.
Journal cover image

Published In

Am J Ind Med

DOI

ISSN

0271-3586

Publication Date

1986

Volume

9

Issue

3

Start / End Page

221 / 226

Location

United States

Related Subject Headings

  • X-Rays
  • Radiography
  • Occupational Diseases
  • Male
  • Lead
  • Humans
  • Fluorescence
  • Environmental Exposure
  • Environmental & Occupational Health
  • Bone and Bones