Failure of low molecular weight dextran to prevent clotting during continuous renal replacement therapy.

Journal Article (Clinical Trial;Journal Article)

Clotting of the extracorporeal circuit during continuous renal replacement therapy results in decreased ultrafiltration rates, impaired solute clearance and, ultimately, occlusion of the extracorporeal circuit. The authors conducted an open-label randomized controlled trial to determine whether low molecular weight dextran could prevent hemofilter clotting in patients undergoing continuous venovenous hemodialysis. Eleven patients were randomized to receive a continuous infusion of 10% low molecular weight dextran at 25 mL/hr; 8 patients served as control subjects. No differences in the frequency of hemofilter clotting or hemofilter lifespan were detected. The authors concluded that continuous infusion of low dose low molecular weight dextran is not effective in preventing clotting during continuous renal replacement therapy.

Full Text

Duke Authors

Cited Authors

  • Palevsky, PM; Burr, R; Moreland, L; Tokiwa, Y; Greenberg, A

Published Date

  • October 1995

Published In

Volume / Issue

  • 41 / 4

Start / End Page

  • 847 - 849

PubMed ID

  • 8589465

International Standard Serial Number (ISSN)

  • 1058-2916


  • eng

Conference Location

  • United States