Caenorhabditis elegans as a host for the study of host-pathogen interactions.


Journal Article (Review)

Recently, pathogenicity models that involve the killing of the genetically tractable nematode Caenorhabditis elegans by human pathogens have been developed. From the perspective of the pathogen, the advantage of these models is that thousands of mutagenized bacterial clones can be individually screened for avirulent mutants on separate petri plates seeded with C. elegans. The advantages of using C. elegans to study host responses to pathogen attack are the extensive genetic and genomic resources available and the relative ease of identifying C. elegans mutants that exhibit altered susceptibility to pathogen attack. The use of Caenorhabditis elegans as the host for a variety of human pathogens is discussed.

Full Text

Cited Authors

  • Aballay, A; Ausubel, FM

Published Date

  • February 2002

Published In

Volume / Issue

  • 5 / 1

Start / End Page

  • 97 - 101

PubMed ID

  • 11834377

Pubmed Central ID

  • 11834377

Electronic International Standard Serial Number (EISSN)

  • 1879-0364

International Standard Serial Number (ISSN)

  • 1369-5274

Digital Object Identifier (DOI)

  • 10.1016/s1369-5274(02)00293-x


  • eng