Caenorhabditis elegans as a host for the study of host-pathogen interactions.
Publication
, Journal Article
Aballay, A; Ausubel, FM
Published in: Current opinion in microbiology
February 2002
Recently, pathogenicity models that involve the killing of the genetically tractable nematode Caenorhabditis elegans by human pathogens have been developed. From the perspective of the pathogen, the advantage of these models is that thousands of mutagenized bacterial clones can be individually screened for avirulent mutants on separate petri plates seeded with C. elegans. The advantages of using C. elegans to study host responses to pathogen attack are the extensive genetic and genomic resources available and the relative ease of identifying C. elegans mutants that exhibit altered susceptibility to pathogen attack. The use of Caenorhabditis elegans as the host for a variety of human pathogens is discussed.
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Published In
Current opinion in microbiology
DOI
EISSN
1879-0364
ISSN
1369-5274
Publication Date
February 2002
Volume
5
Issue
1
Start / End Page
97 / 101
Related Subject Headings
- Virulence
- Signal Transduction
- Pseudomonas aeruginosa
- Mutagenesis, Insertional
- Microbiology
- Humans
- Host-Parasite Interactions
- Gram-Positive Bacterial Infections
- Gene Expression
- Caenorhabditis elegans
Citation
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Chicago
ICMJE
MLA
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Aballay, A., & Ausubel, F. M. (2002). Caenorhabditis elegans as a host for the study of host-pathogen interactions. Current Opinion in Microbiology, 5(1), 97–101. https://doi.org/10.1016/s1369-5274(02)00293-x
Aballay, Alejandro, and Frederick M. Ausubel. “Caenorhabditis elegans as a host for the study of host-pathogen interactions.” Current Opinion in Microbiology 5, no. 1 (February 2002): 97–101. https://doi.org/10.1016/s1369-5274(02)00293-x.
Aballay A, Ausubel FM. Caenorhabditis elegans as a host for the study of host-pathogen interactions. Current opinion in microbiology. 2002 Feb;5(1):97–101.
Aballay, Alejandro, and Frederick M. Ausubel. “Caenorhabditis elegans as a host for the study of host-pathogen interactions.” Current Opinion in Microbiology, vol. 5, no. 1, Feb. 2002, pp. 97–101. Epmc, doi:10.1016/s1369-5274(02)00293-x.
Aballay A, Ausubel FM. Caenorhabditis elegans as a host for the study of host-pathogen interactions. Current opinion in microbiology. 2002 Feb;5(1):97–101.
Published In
Current opinion in microbiology
DOI
EISSN
1879-0364
ISSN
1369-5274
Publication Date
February 2002
Volume
5
Issue
1
Start / End Page
97 / 101
Related Subject Headings
- Virulence
- Signal Transduction
- Pseudomonas aeruginosa
- Mutagenesis, Insertional
- Microbiology
- Humans
- Host-Parasite Interactions
- Gram-Positive Bacterial Infections
- Gene Expression
- Caenorhabditis elegans