Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity.

Published

Journal Article

The endoplasmic reticulum stress response, also known as the unfolded protein response (UPR), has been implicated in the normal physiology of immune defense and in several disorders, including diabetes, cancer, and neurodegenerative disease. Here, we show that the apoptotic receptor CED-1 and a network of PQN/ABU proteins involved in a noncanonical UPR response are required for proper defense to pathogen infection in Caenorhabditis elegans. A full-genome microarray analysis indicates that CED-1 functions to activate the expression of pqn/abu genes. We also show that ced-1 and pqn/abu genes are required for the survival of C. elegans exposed to live Salmonella enterica, and that overexpression of pqn/abu genes confers protection against pathogen-mediated killing. The results indicate that unfolded protein response genes, regulated in a CED-1-dependent manner, are involved in the C. elegans immune response to live bacteria.

Full Text

Duke Authors

Cited Authors

  • Haskins, KA; Russell, JF; Gaddis, N; Dressman, HK; Aballay, A

Published Date

  • July 2008

Published In

Volume / Issue

  • 15 / 1

Start / End Page

  • 87 - 97

PubMed ID

  • 18606143

Pubmed Central ID

  • 18606143

Electronic International Standard Serial Number (EISSN)

  • 1878-1551

International Standard Serial Number (ISSN)

  • 1534-5807

Digital Object Identifier (DOI)

  • 10.1016/j.devcel.2008.05.006

Language

  • eng