Heat-shock transcription factor (HSF)-1 pathway required for Caenorhabditis elegans immunity.


Journal Article

Innate immunity comprises physical barriers, pattern-recognition receptors, antimicrobial substances, phagocytosis, and fever. Here we report that increased temperature results in the activation of a conserved pathway involving the heat-shock (HS) transcription factor (HSF)-1 that enhances immunity in the invertebrate Caenorhabditis elegans. The HSF-1 defense response is independent of the p38 MAPK/PMK-1 pathway and requires a system of chaperones including small and 90-kDa inducible HS proteins. In addition, HSF-1 is needed for the effects of the DAF-2 insulin-like pathway in defense to pathogens, indicating that interacting pathways control stress response, aging, and immunity. The results also show that HSF-1 is required for C. elegans immunity against Pseudomonas aeruginosa, Salmonella enterica, Yersinia pestis, and Enterococcus faecalis, indicating that HSF-1 is part of a multipathogen defense pathway. Considering that several coinducers of HSF-1 are currently in clinical trials, this work opens the possibility that activation of HSF-1 could be used to boost immunity to treat infectious diseases and immunodeficiencies.

Full Text

Cited Authors

  • Singh, V; Aballay, A

Published Date

  • August 17, 2006

Published In

Volume / Issue

  • 103 / 35

Start / End Page

  • 13092 - 13097

PubMed ID

  • 16916933

Pubmed Central ID

  • 16916933

Electronic International Standard Serial Number (EISSN)

  • 1091-6490

International Standard Serial Number (ISSN)

  • 1091-6490

Digital Object Identifier (DOI)

  • 10.1073/pnas.0604050103


  • eng