A structured review of randomized controlled trials of weight loss showed little improvement in health-related quality of life.


Journal Article (Review)

OBJECTIVE: To estimate the effect of weight-loss interventions on health-related quality of life (HrQoL) in randomized controlled trials (RCTs); to conduct a meta-analysis of weight-loss treatment on depressive symptoms; and, to examine methodological and presentation issues that compromise study validity. STUDY DESIGN AND SETTING: We conducted a structured review of 34 RCTs with weight-loss interventions that reported the relationship between HrQoL and treatment at two or more time points. We also evaluated study quality. RESULTS: Trials lasted 6 weeks to 208 weeks and evaluated behavioral, surgical, or pharmacologic interventions. Nine of 34 trials showed HrQoL improvements in generic measures. Obesity-specific measures were more likely to show improvement in response to treatment than non-obesity-specific measures. Meta-analysis showed no treatment effect on depressive symptoms. Most trials tracked loss to follow-up and conducted intent-to-treat analysis, but only four trials concealed recruitment staff to randomization and 14 blinded the investigation team to randomization. CONCLUSION: HrQoL outcomes, including depression, were not consistently improved in RCTs of weight loss. The overall quality of these clinical trials was poor. Better-designed RCTs using standardized HrQoL measures are needed to determine the extent to which weight loss improves HrQoL.

Full Text

Duke Authors

Cited Authors

  • Maciejewski, ML; Patrick, DL; Williamson, DF

Published Date

  • June 2005

Published In

Volume / Issue

  • 58 / 6

Start / End Page

  • 568 - 578

PubMed ID

  • 15878470

Pubmed Central ID

  • 15878470

International Standard Serial Number (ISSN)

  • 0895-4356

Digital Object Identifier (DOI)

  • 10.1016/j.jclinepi.2004.10.015


  • eng

Conference Location

  • United States