Linearity of the accumulation of various dosages of uranium in the major organs of mature male Japanese quail. Effect of various doses of estradiol-17 beta.


Journal Article

1. Male Japanese quail were given 2.20 x 10(-4)-14.53 mg uranium/kg intravenously as uranyl ion (235U label). 2. The relationship between dosage and the 18-hr accumulation of U in leg bones, liver, kidneys and testes was linear. 3. Increases in U deposition with increased dosage were approximately 1:1, except for kidneys where 10-fold increases in dosage resulted in 25-fold increases in deposition. 4. Estradiol-17 beta increased U deposition in bones by 15-fold thereby providing some protection for the kidneys as now the ratio of dosage to accumulation was 1:1.

Full Text

Cited Authors

  • Kupsh, CC; Robinson, GA

Published Date

  • January 1989

Published In

Volume / Issue

  • 92 / 1

Start / End Page

  • 55 - 59

PubMed ID

  • 2566445

Pubmed Central ID

  • 2566445

International Standard Serial Number (ISSN)

  • 0742-8413

Digital Object Identifier (DOI)

  • 10.1016/0742-8413(89)90202-8


  • eng