Studies with radioactive endotoxin. I. Clearance of 51Cr-labelled endotoxin from the blood of calves.


Journal Article

The clearance of (51)Cr-labelled Pseudomonas endotoxin from the blood was studied in calves in a nontolerant and in an endotoxin-tolerant state. Calves were rendered tolerant to the toxic effects of the endotoxin by four daily intravenous injections of endotoxin at the dose rate of 5 microg/kg body weight. Clearance of a small amount of (51)Cr-endotoxin from the blood of nontolerant calves was almost complete within three minutes of injection and was not significantly faster in tolerant calves. The lungs and liver were the major organs involved in clearance of endotoxin from the blood. The (51)Cr label was slowly excreted by the kidneys. Neither platelets nor leukocytes were demonstrated to participate in endotoxin clearance in calves. (51)CrCl(3) was injected into control calves. Relative to the distribution and loss of labelled endotoxin, the (51)CrCl(3) was cleared slowly from the blood, was distributed uniformly throughout the body and was excreted rapidly.

Full Text

Cited Authors

  • Maxie, MG; Valli, VE; Robinson, GA; Truscott, RB; McSherry, BJ

Published Date

  • October 1, 1974

Published In

Volume / Issue

  • 38 / 4

Start / End Page

  • 347 - 366

PubMed ID

  • 4279754

Pubmed Central ID

  • 4279754

International Standard Serial Number (ISSN)

  • 0008-4050


  • eng