Helicobacter typhlonius and Helicobacter rodentium differentially affect the severity of colon inflammation and inflammation-associated neoplasia in IL10-deficient mice.
Publication
, Journal Article
Chichlowski, M; Sharp, JM; Vanderford, DA; Myles, MH; Hale, LP
Published in: Comp Med
December 2008
Infection with Helicobacter species is endemic in many animal facilities and may alter the penetrance of inflammatory bowel disease (IBD) phenotypes. However, little is known about the relative pathogenicity of H. typhlonius, H. rodentium, and combined infection in IBD models. We infected adult and neonatal IL10-/- mice with H. typhlonius, H. rodentium, or both bacteria. The severity of IBD and incidence of inflammation-associated colonic neoplasia were assessed in the presence and absence of antiHelicobacter therapy. Infected IL10-/- mice developed IBD with severity of noninfected (minimal to no inflammation) < H. rodentium < H. typhlonius
Duke Scholars
Published In
Comp Med
ISSN
1532-0820
Publication Date
December 2008
Volume
58
Issue
6
Start / End Page
534 / 541
Location
United States
Related Subject Headings
- Veterinary Sciences
- Species Specificity
- Mice, Knockout
- Mice, Inbred C57BL
- Mice
- Male
- Interleukin-10
- Inflammatory Bowel Diseases
- Helicobacter Infections
- Helicobacter
Citation
APA
Chicago
ICMJE
MLA
NLM
Chichlowski, M., Sharp, J. M., Vanderford, D. A., Myles, M. H., & Hale, L. P. (2008). Helicobacter typhlonius and Helicobacter rodentium differentially affect the severity of colon inflammation and inflammation-associated neoplasia in IL10-deficient mice. Comp Med, 58(6), 534–541.
Chichlowski, Maciej, Julie M. Sharp, Deborah A. Vanderford, Matthew H. Myles, and Laura P. Hale. “Helicobacter typhlonius and Helicobacter rodentium differentially affect the severity of colon inflammation and inflammation-associated neoplasia in IL10-deficient mice.” Comp Med 58, no. 6 (December 2008): 534–41.
Chichlowski M, Sharp JM, Vanderford DA, Myles MH, Hale LP. Helicobacter typhlonius and Helicobacter rodentium differentially affect the severity of colon inflammation and inflammation-associated neoplasia in IL10-deficient mice. Comp Med. 2008 Dec;58(6):534–41.
Chichlowski, Maciej, et al. “Helicobacter typhlonius and Helicobacter rodentium differentially affect the severity of colon inflammation and inflammation-associated neoplasia in IL10-deficient mice.” Comp Med, vol. 58, no. 6, Dec. 2008, pp. 534–41.
Chichlowski M, Sharp JM, Vanderford DA, Myles MH, Hale LP. Helicobacter typhlonius and Helicobacter rodentium differentially affect the severity of colon inflammation and inflammation-associated neoplasia in IL10-deficient mice. Comp Med. 2008 Dec;58(6):534–541.
Published In
Comp Med
ISSN
1532-0820
Publication Date
December 2008
Volume
58
Issue
6
Start / End Page
534 / 541
Location
United States
Related Subject Headings
- Veterinary Sciences
- Species Specificity
- Mice, Knockout
- Mice, Inbred C57BL
- Mice
- Male
- Interleukin-10
- Inflammatory Bowel Diseases
- Helicobacter Infections
- Helicobacter