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Helicobacter typhlonius and Helicobacter rodentium differentially affect the severity of colon inflammation and inflammation-associated neoplasia in IL10-deficient mice.

Publication ,  Journal Article
Chichlowski, M; Sharp, JM; Vanderford, DA; Myles, MH; Hale, LP
Published in: Comp Med
December 2008

Infection with Helicobacter species is endemic in many animal facilities and may alter the penetrance of inflammatory bowel disease (IBD) phenotypes. However, little is known about the relative pathogenicity of H. typhlonius, H. rodentium, and combined infection in IBD models. We infected adult and neonatal IL10-/- mice with H. typhlonius, H. rodentium, or both bacteria. The severity of IBD and incidence of inflammation-associated colonic neoplasia were assessed in the presence and absence of antiHelicobacter therapy. Infected IL10-/- mice developed IBD with severity of noninfected (minimal to no inflammation) < H. rodentium < H. typhlonius

Duke Scholars

Published In

Comp Med

ISSN

1532-0820

Publication Date

December 2008

Volume

58

Issue

6

Start / End Page

534 / 541

Location

United States

Related Subject Headings

  • Veterinary Sciences
  • Species Specificity
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Interleukin-10
  • Inflammatory Bowel Diseases
  • Helicobacter Infections
  • Helicobacter
 

Citation

APA
Chicago
ICMJE
MLA
NLM

Published In

Comp Med

ISSN

1532-0820

Publication Date

December 2008

Volume

58

Issue

6

Start / End Page

534 / 541

Location

United States

Related Subject Headings

  • Veterinary Sciences
  • Species Specificity
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Interleukin-10
  • Inflammatory Bowel Diseases
  • Helicobacter Infections
  • Helicobacter