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Bacterial-mucosal interactions in inflammatory bowel disease: an alliance gone bad.

Publication ,  Journal Article
Chichlowski, M; Hale, LP
Published in: Am J Physiol Gastrointest Liver Physiol
December 2008

The complex interaction of genetic, microbial, and environmental factors may result in continuous activation of the mucosal immune system leading to inflammatory bowel disease (IBD). Most present treatments for IBD involve altering or suppressing the aberrant immune response; however, the role of the intestinal microbiota in the pathophysiology of IBD is becoming more evident. The epithelial layer is essential for the proper functioning of the gastrointestinal tract, and its increased permeability to the luminal antigens may lead to the inflammatory processes and mucosal damage observed in IBD. Factors affecting the efficacy of the epithelial barrier include presence of pathogenic bacteria (e.g., Helicobacter spp.), presence of probiotic bacteria, availability of selected nutrients, and others. Defective function of the mucosal barrier might facilitate the contact of bacterial antigens and adjuvants with innate and adaptive immune cells to generate prolonged inflammatory responses. This review will briefly describe the complex structure of the epithelial barrier in the context of bacterial-mucosal interactions observed in human IBD and mouse models of colitis.

Duke Scholars

Published In

Am J Physiol Gastrointest Liver Physiol

DOI

ISSN

0193-1857

Publication Date

December 2008

Volume

295

Issue

6

Start / End Page

G1139 / G1149

Location

United States

Related Subject Headings

  • Permeability
  • Models, Animal
  • Mice
  • Membrane Microdomains
  • Intestinal Mucosa
  • Inflammatory Bowel Diseases
  • Humans
  • Gastroenterology & Hepatology
  • Epithelial Cells
  • Bacterial Infections
 

Citation

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Chicago
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MLA
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Chichlowski, M., & Hale, L. P. (2008). Bacterial-mucosal interactions in inflammatory bowel disease: an alliance gone bad. Am J Physiol Gastrointest Liver Physiol, 295(6), G1139–G1149. https://doi.org/10.1152/ajpgi.90516.2008
Chichlowski, Maciej, and Laura P. Hale. “Bacterial-mucosal interactions in inflammatory bowel disease: an alliance gone bad.Am J Physiol Gastrointest Liver Physiol 295, no. 6 (December 2008): G1139–49. https://doi.org/10.1152/ajpgi.90516.2008.
Chichlowski M, Hale LP. Bacterial-mucosal interactions in inflammatory bowel disease: an alliance gone bad. Am J Physiol Gastrointest Liver Physiol. 2008 Dec;295(6):G1139–49.
Chichlowski, Maciej, and Laura P. Hale. “Bacterial-mucosal interactions in inflammatory bowel disease: an alliance gone bad.Am J Physiol Gastrointest Liver Physiol, vol. 295, no. 6, Dec. 2008, pp. G1139–49. Pubmed, doi:10.1152/ajpgi.90516.2008.
Chichlowski M, Hale LP. Bacterial-mucosal interactions in inflammatory bowel disease: an alliance gone bad. Am J Physiol Gastrointest Liver Physiol. 2008 Dec;295(6):G1139–G1149.

Published In

Am J Physiol Gastrointest Liver Physiol

DOI

ISSN

0193-1857

Publication Date

December 2008

Volume

295

Issue

6

Start / End Page

G1139 / G1149

Location

United States

Related Subject Headings

  • Permeability
  • Models, Animal
  • Mice
  • Membrane Microdomains
  • Intestinal Mucosa
  • Inflammatory Bowel Diseases
  • Humans
  • Gastroenterology & Hepatology
  • Epithelial Cells
  • Bacterial Infections