The effect of chronic L-dopa administration on supersensitive pre- and postsynaptic dopaminergic receptors in rat brain.
Journal Article (Journal Article)
Chronic administration of haloperidol induced supersensitivity of the pre- and postsynaptic dopaminergic receptors in rat brain. The response of the presynaptic receptors was determined by an enhanced inhibitory effect of apomorphine on dopamine synthesis after gamma-butyrolactone injection. This change in the receptor function was detected both in the nigrostriatal and mesolimbic pathways. Haloperidol also increased the 3H-spiperone binding sites in striatal membranes, indicating supersensitivity of the postsynaptic receptors. Subsequent prolonged treatment with high doses of L-DOPA/carbidopa resulted in a decrease in 3H-spiperone binding sites, but had no effect on the supersensitive presynaptic receptors. It is suggested that tardive dyskinesia may be a state of both pre- and postsynaptic dopamine receptor supersensitivity and that chronic L-DOPA treatment may have a differential effect on these sites.
Full Text
Duke Authors
Cited Authors
- Reches, A; Wagner, HR; Jiang, D; Jackson, V; Fahn, S
Published Date
- July 5, 1982
Published In
Volume / Issue
- 31 / 1
Start / End Page
- 37 - 44
PubMed ID
- 7109853
International Standard Serial Number (ISSN)
- 0024-3205
Digital Object Identifier (DOI)
- 10.1016/0024-3205(82)90398-8
Language
- eng
Conference Location
- Netherlands