Clonazepam-induced up-regulation of serotonin1 binding sites in frontal cortex of rat.
Journal Article (Journal Article)
Chronic administration of the benzodiazepine, clonazepam, increased the number of [3H]5-hydroxytryptamine (5-HT1) binding sites in the frontal cortex of the rat. The increase reflected a change in the maximum density of binding sites (Bmax) with no change in ligand affinity (Kd). Increased binding occurred after continued exposure (10 days) to large (5.0 mg/kg) doses of clonazepam. The changes in [3H]5-HT binding were regional in that they occurred in membranes from the frontal cortex but not the brainstem. The effects were also at least partially selective for 5-HT receptors since the binding of the beta-adrenergic radioligand, [3H]dihydroalprenolol, was not affected by clonazepam. A second benzodiazepine, diazepam, did not affect the binding of [3H]5-HT at doses of 30 mg/kg per day. The latter data suggest that the effects of benzodiazepines on serotonin 5-HT1 receptors are unique to clonazepam.
Full Text
Duke Authors
Cited Authors
- Wagner, HR; Reches, A; Fahn, S
Published Date
- October 1985
Published In
Volume / Issue
- 24 / 10
Start / End Page
- 953 - 956
PubMed ID
- 2415867
International Standard Serial Number (ISSN)
- 0028-3908
Digital Object Identifier (DOI)
- 10.1016/0028-3908(85)90121-2
Language
- eng
Conference Location
- England