Clonazepam-induced up-regulation of serotonin1 binding sites in frontal cortex of rat.

Journal Article (Journal Article)

Chronic administration of the benzodiazepine, clonazepam, increased the number of [3H]5-hydroxytryptamine (5-HT1) binding sites in the frontal cortex of the rat. The increase reflected a change in the maximum density of binding sites (Bmax) with no change in ligand affinity (Kd). Increased binding occurred after continued exposure (10 days) to large (5.0 mg/kg) doses of clonazepam. The changes in [3H]5-HT binding were regional in that they occurred in membranes from the frontal cortex but not the brainstem. The effects were also at least partially selective for 5-HT receptors since the binding of the beta-adrenergic radioligand, [3H]dihydroalprenolol, was not affected by clonazepam. A second benzodiazepine, diazepam, did not affect the binding of [3H]5-HT at doses of 30 mg/kg per day. The latter data suggest that the effects of benzodiazepines on serotonin 5-HT1 receptors are unique to clonazepam.

Full Text

Duke Authors

Cited Authors

  • Wagner, HR; Reches, A; Fahn, S

Published Date

  • October 1985

Published In

Volume / Issue

  • 24 / 10

Start / End Page

  • 953 - 956

PubMed ID

  • 2415867

International Standard Serial Number (ISSN)

  • 0028-3908

Digital Object Identifier (DOI)

  • 10.1016/0028-3908(85)90121-2


  • eng

Conference Location

  • England