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beta-Adrenergic receptor regulation by agonists and membrane depolarization in rat brain slices.

Publication ,  Journal Article
Wagner, HR; Davis, JN
Published in: Proc Natl Acad Sci U S A
April 1979

Rat cerebral cortex slices exposed to (-)-isoproterenol and then washed accumulated significantly less cyclic AMP when rechallenged with isoproterenol than did control slices. The isoproterenol-induced desensitization was associated with a concurrent reduction in [3H]dihydroalprenolol membrane binding but with no change in the affinity of [3H]dihydroalprenolol or isoproterenol for the binding sites. beta-Adrenergic receptor desensitization was rapidly reversed by slice depolarization with high-[K+] buffers, batrachotoxin, grayanotoxin, or veratridine, even in the continued presence of isoproterenol. Restoration of binding by grayanotoxin was prevented by tetrodotoxin or by removing Na+ from the buffer. These data demonstrate partial participation of the membrane receptor in beta-adrenergic desensitization of rat brain slices and suggest that brain beta-adrenergic receptors, like cholinergic receptors in skeletal muscle and alpha-adrenergic receptors in rat parotid, are regulated in part by membrane voltage.

Duke Scholars

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

April 1979

Volume

76

Issue

4

Start / End Page

2057 / 2061

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic
  • Rats
  • Radioligand Assay
  • Norepinephrine
  • Male
  • Kinetics
  • Isoproterenol
  • In Vitro Techniques
  • Epinephrine
 

Citation

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Wagner, H. R., & Davis, J. N. (1979). beta-Adrenergic receptor regulation by agonists and membrane depolarization in rat brain slices. Proc Natl Acad Sci U S A, 76(4), 2057–2061. https://doi.org/10.1073/pnas.76.4.2057
Wagner, H. R., and J. N. Davis. “beta-Adrenergic receptor regulation by agonists and membrane depolarization in rat brain slices.Proc Natl Acad Sci U S A 76, no. 4 (April 1979): 2057–61. https://doi.org/10.1073/pnas.76.4.2057.
Wagner HR, Davis JN. beta-Adrenergic receptor regulation by agonists and membrane depolarization in rat brain slices. Proc Natl Acad Sci U S A. 1979 Apr;76(4):2057–61.
Wagner, H. R., and J. N. Davis. “beta-Adrenergic receptor regulation by agonists and membrane depolarization in rat brain slices.Proc Natl Acad Sci U S A, vol. 76, no. 4, Apr. 1979, pp. 2057–61. Pubmed, doi:10.1073/pnas.76.4.2057.
Wagner HR, Davis JN. beta-Adrenergic receptor regulation by agonists and membrane depolarization in rat brain slices. Proc Natl Acad Sci U S A. 1979 Apr;76(4):2057–2061.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

April 1979

Volume

76

Issue

4

Start / End Page

2057 / 2061

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic
  • Rats
  • Radioligand Assay
  • Norepinephrine
  • Male
  • Kinetics
  • Isoproterenol
  • In Vitro Techniques
  • Epinephrine