Localization of the L-glutamine synthetase gene to chromosome 1q23.


Journal Article

Glutamine synthetase (E.C. is expressed throughout the body and plays an important role in controlling body pH and in removing ammonia from the circulation. The enzyme clears L-glutamate, the major neurotransmitter in the central nervous system, from neuronal synapses. The enzyme is a very sensitive marker of many disease and aging processes, especially those involving reactive oxygen species. This report describes the localization of the enzyme to chromosome 1 by PCR analysis of a human/rodent somatic cell hybrid panel. We also describe the localization of a recently described pseudogene to chromosome 9. Further localization of the glutamine synthetase gene locus to 1q23 was accomplished by fluorescence in situ hybridization. The glutamine synthetase gene was mapped to five CEPH megaYACs between the polymorphic PCR markers D1S117 and D1S466 by analysis of the Whitehead Institute's recently described chromosome 1 contig map.

Full Text

Cited Authors

  • Clancy, KP; Berger, R; Cox, M; Bleskan, J; Walton, KA; Hart, I; Patterson, D

Published Date

  • December 1996

Published In

Volume / Issue

  • 38 / 3

Start / End Page

  • 418 - 420

PubMed ID

  • 8975719

Pubmed Central ID

  • 8975719

Electronic International Standard Serial Number (EISSN)

  • 1089-8646

International Standard Serial Number (ISSN)

  • 0888-7543

Digital Object Identifier (DOI)

  • 10.1006/geno.1996.0645


  • eng