Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage.


Journal Article

OBJECTIVE: To determine the relationship between the apolipoprotein E (APOE) epsilon4 allele and in-hospital mortality from intracerebral haemorrhage (ICH). MATERIAL AND METHODS: Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients. RESULTS: There were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOEepsilon4 allele (P = 0.026) significantly reduced in-hospital survival. CONCLUSION: The APOEepsilon4 allele in this population may be associated with poor survival following ICH.

Full Text

Duke Authors

Cited Authors

  • McCarron, MO; Weir, CJ; Muir, KW; Hoffmann, KL; Graffagnino, C; Nicoll, JAR; Lees, KR; Alberts, MJ

Published Date

  • February 2003

Published In

Volume / Issue

  • 107 / 2

Start / End Page

  • 106 - 109

PubMed ID

  • 12580859

Pubmed Central ID

  • 12580859

International Standard Serial Number (ISSN)

  • 0001-6314

Digital Object Identifier (DOI)

  • 10.1034/j.1600-0404.2003.01365.x


  • eng

Conference Location

  • Denmark